Research workbench
Fusion protein of heme oxygenase-1 and NADPH-cytochrome P450 reductase (13aa)
Analyse Fusion protein of heme oxygenase-1 and NADPH-cytochrome P450 reductase (13aa) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6J79
- Type
- protein
- Length
- 1,629 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 3.331
- Source
- Rattus norvegicus
- Molecule
- Heme oxygenase 1,NADPH--cytochrome P450 reductase
- EC
- 1.14.14.18, 1.6.2.4
- UniProt
- P06762, P00388
- Ligands
- FAD, FMN, HEM
- Pockets
- 20 · best druggability 0.77
Structure
x-ray diffraction · resolution 3.331 · 2 distinct chains · 46% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Heme oxygenase 1,NADPH--cytochrome P450 reductase (EC 1.14.14.18, 1.6.2.4) | protein | 816 | 46% helix, 16% strand | P06762, P00388 |
| B | Heme oxygenase 1,NADPH--cytochrome P450 reductase (EC 1.14.14.18, 1.6.2.4) | protein | 813 | 47% helix, 15% strand | P06762, P00388 |
Ligands and binding sites
- FAD · Flavin-adenine dinucleotide · ligand · 2 copies · chains A, B
- FMN · Flavin mononucleotide · ligand · 2 copies · chains A, B
- HEM · Protoporphyrin IX containing Fe · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 499 | 0.77 | 0.84 | 45 | HEM |
| 2 | 459 | 0.76 | 0.84 | 47 | HEM |
| 3 | 813 | 0.74 | 0.79 | 72 | empty |
| 4 | 674 | 0.73 | 0.80 | 99 | FAD |
| 5 | 587 | 0.73 | 0.81 | 54 | empty |
Interfaces
1 interface between chains.
- A–B · 1656 Ų buried · 32 hydrogen bonds · protein-protein
Compared structures
- 6J79 · Fusion protein of heme oxygenase-1 and NADPH-cytochrome P450 reductase (13AA) · the same entry in another collection · chain A against A, TM-score 1.00
- P00388 · AlphaFold monomer V2.0 prediction for NADPH--cytochrome P450 reductase (P00388) · a predicted model of the same protein · chain A against A, TM-score 0.60
- P06762 · AlphaFold monomer V2.0 prediction for heme oxygenase 1 (P06762) · a predicted model of the same protein · chain B against A, TM-score 0.28
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06762
- Every structure of UniProt P00388
- Elsewhere: RCSB PDB 6J79 · PDBe 6J79 · UniProt P06762 · UniProt P00388
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