Research workbench
Dimeric human TCTP
Analyse Dimeric human TCTP in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6IZE
- Type
- protein
- Length
- 572 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.29
- Source
- Homo sapiens
- Molecule
- Translationally-controlled tumor protein
- UniProt
- P13693
- Pockets
- 6 · best druggability 0.61
Structure
x-ray diffraction · resolution 2.29 · 1 distinct chain · 37% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Translationally-controlled tumor protein | protein | 143 | 37% helix, 31% strand | P13693 |
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 108 | 0.61 | 0.87 | 29 | empty |
| 2 | 215 | 0.56 | 0.79 | 31 | empty |
| 3 | 144 | 0.42 | 0.75 | 17 | empty |
| 4 | 53 | 0.28 | 0.74 | 12 | empty |
| 5 | 55 | 0.28 | 0.74 | 14 | empty |
Interfaces
3 interfaces between chains.
- C–D · 696 Ų buried · 4 hydrogen bonds · protein-protein
- A–B · 681 Ų buried · 4 hydrogen bonds · protein-protein
- B–C · 565 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P13693
- Elsewhere: RCSB PDB 6IZE · PDBe 6IZE · UniProt P13693
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