MolNFT v1 · #152973 · protein

Dimeric human tctp

6IZE · Translationally-controlled tumor protein: “Dimeric human tctp”. X-ray diffraction, 6 pockets (best druggability 0.61). MolNFT v1 #152973 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6IZE
Type: protein
Length: 572 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Translationally-controlled tumor protein
UniProt: P13693
Pockets: 6 · best druggability 0.61

Structure

x-ray diffraction · 1 distinct chain · 37% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Translationally-controlled tumor protein	protein	143	37% helix, 31% strand	P13693

Pockets

6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	108	0.61	0.87	29	empty
2	215	0.56	0.79	31	empty
3	144	0.42	0.75	17	empty
4	53	0.28	0.74	12	empty
5	55	0.28	0.74	14	empty

Interfaces

3 interfaces between chains.

C–D · 696 Å² buried · 4 hydrogen bonds · protein-protein
A–B · 681 Å² buried · 4 hydrogen bonds · protein-protein
B–C · 565 Å² buried · 4 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

6IZE · Dimeric human TCTP · the same entry in another collection · chain A against A, TM-score 1.00
P13693 · AlphaFold monomer V2.0 prediction for translationally-controlled tumor protein (P13693) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P13693
Elsewhere: RCSB PDB 6IZE · PDBe 6IZE · UniProt P13693

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