Research workbench
Structure of the C-terminal domain of USP25 (748-1048)
Analyse Structure of the C-terminal domain of USP25 (748-1048) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6HEM
- Type
- protein
- Length
- 300 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 1.72
- Source
- Homo sapiens
- Molecule
- Ubiquitin carboxyl-terminal hydrolase 25
- EC
- 3.4.19.12
- UniProt
- Q9UHP3
- Ligands
- NA
- Pockets
- 3 · best druggability 0.55
Structure
x-ray diffraction · resolution 1.72 · 1 distinct chain · 72% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ubiquitin carboxyl-terminal hydrolase 25 (EC 3.4.19.12) | protein | 300 | 72% helix, 0% strand | Q9UHP3 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 280 | 0.55 | 0.76 | 30 | empty |
| 2 | 142 | 0.43 | 0.75 | 24 | NA |
| 3 | 113 | 0.42 | 0.76 | 26 | GOL |
Compared structures
- 6HEM · Structure of the C-terminal domain of USP25 (748-1048) · the same entry in another collection · chain A against A, TM-score 1.00
- Q9UHP3 · AlphaFold monomer V2.0 prediction for ubiquitin carboxyl-terminal hydrolase 25 (Q9UHP3) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UHP3
- Elsewhere: RCSB PDB 6HEM · PDBe 6HEM · UniProt Q9UHP3
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.