Research workbench
Serum paraoxonase-1 by directed evolution with the L69G/H134R/F222S/T332S mutations
Analyse Serum paraoxonase-1 by directed evolution with the L69G/H134R/F222S/T332S… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6GMU
- Type
- protein
- Length
- 338 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.7
- Source
- Homo sapiens
- Molecule
- Serum Paraoxonase-1 by directed evolution with the L69G/H134R/F222S/T332S mutations
- Ligands
- CA, CL
- Pockets
- 2 · best druggability 0.74
Structure
x-ray diffraction · resolution 2.7 · 1 distinct chain · 7% helix, 47% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Serum Paraoxonase-1 by directed evolution with the L69G/H134R/F222S/T332S mutations | protein | 338 | 7% helix, 47% strand | — |
Ligands and binding sites
- CA · Calcium ion · metal · 2 copies · chains A
- CL · Chloride ion · ion · 3 copies · chains A
- B3P · 2-[3-(2-hydroxy-1,1-dihydroxymethyl-ethylamino)-propylamino]-2-hydroxymethyl-propane-1,3-diol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 216 | 0.74 | 0.89 | 27 | CA |
| 2 | 289 | 0.62 | 0.80 | 36 | CA |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 6GMU · Serum paraoxonase-1 by directed evolution with the L69G/H134R/F222S/T332S mutations · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6GMU · PDBe 6GMU
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