MolNFT v1 · #150209 · protein
Serum paraoxonase-1 by directed evolution with the L69G/H134R/F222S/T332S mutations
6GMU: “Serum paraoxonase-1 by directed evolution with the L69G/H134R/F222S/T332S mutations”. X-ray diffraction, 2 ligands (CA, CL), 2 pockets (best druggability 0.74). MolNFT v1 #150209 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 6GMU
- Type
- protein
- Length
- 338 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Serum paraoxonase-1 by directed evolution with the L69G/H134R/F222S/T332S mutations
- Ligands
- CA, CL
- Pockets
- 2 · best druggability 0.74
Structure
x-ray diffraction · 1 distinct chain · 7% helix, 47% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Serum paraoxonase-1 by directed evolution with the L69G/H134R/F222S/T332S mutations | protein | 338 | 7% helix, 47% strand | — |
Ligands and binding sites
- CA · Calcium ion · metal · 2 copies · chains A
- CL · Chloride ion · ion · 3 copies · chains A
- B3P · 2-[3-(2-hydroxy-1,1-dihydroxymethyl-ethylamino)-propylamino]-2-hydroxymethyl-propane-1,3-diol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 216 | 0.74 | 0.89 | 27 | CA |
| 2 | 289 | 0.62 | 0.80 | 36 | CA |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 6GMU · Serum paraoxonase-1 by directed evolution with the L69G/H134R/F222S/T332S mutations · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6GMU · PDBe 6GMU
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.