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Crystal Structure of the YopH PTP1B Chimera 3 PTPase bound to vanadate

Analyse Crystal Structure of the YopH PTP1B Chimera 3 PTPase bound to vanadate in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6DT6
Type: protein
Length: 282 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 2.101
Source: Yersinia pestis
Molecule: Targeted effector protein
UniProt: O68720
Ligands: VO4
Pockets: 2 · best druggability 0.47

Structure

x-ray diffraction · resolution 2.101 · 1 distinct chain · 39% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Targeted effector protein	protein	282	39% helix, 21% strand	O68720

Ligands and binding sites

VO4 · Vanadate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	148	0.47	0.77	21	empty
2	62	0.30	0.75	15	VO4

Compared structures

6DT6 · Crystal structure of the yoph PTP1B chimera 3 ptpase bound to vanadate · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O68720
Elsewhere: RCSB PDB 6DT6 · PDBe 6DT6 · UniProt O68720

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