MolNFT v1 · #146806 · protein
Crystal structure of the yoph PTP1B chimera 3 ptpase bound to vanadate
6DT6 · Targeted effector protein: “Crystal structure of the yoph PTP1B chimera 3 ptpase bound to vanadate”. X-ray diffraction, 1 ligand (VO4), 2 pockets (best druggability 0.47). MolNFT v1 #146806 on GenesisL1: 3D structure, binding sites…
- PDB
- 6DT6
- Type
- protein
- Length
- 282 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Targeted effector protein
- UniProt
- O68720
- Ligands
- VO4
- Pockets
- 2 · best druggability 0.47
Structure
x-ray diffraction · 1 distinct chain · 39% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Targeted effector protein | protein | 282 | 39% helix, 21% strand | O68720 |
Ligands and binding sites
- VO4 · Vanadate ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 148 | 0.47 | 0.77 | 21 | empty |
| 2 | 62 | 0.30 | 0.75 | 15 | VO4 |
Compared structures
- 6DT6 · Crystal Structure of the YopH PTP1B Chimera 3 PTPase bound to vanadate · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O68720
- Elsewhere: RCSB PDB 6DT6 · PDBe 6DT6 · UniProt O68720
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