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Human biliverdin IX beta reductase: NADP/Phloxine B ternary complex

Analyse Human biliverdin IX beta reductase: NADP/Phloxine B ternary complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
5OOG
Type
protein
Length
205 residues
Chains
1
Method
x-ray diffraction
Collection
MolNFT v2 / PDB Bank
Contract
0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner
0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution
1.33
Source
Homo sapiens
Molecule
Flavin reductase (NADPH)
EC
1.5.1.30, 1.3.1.24
UniProt
P30043
Ligands
A0B, NAP, PO4
Pockets
1 · best druggability 0.72

Structure

x-ray diffraction · resolution 1.33 · 1 distinct chain · 38% helix, 21% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
AFlavin reductase (NADPH) (EC 1.5.1.30, 1.3.1.24)protein20538% helix, 21% strandP30043

Ligands and binding sites

  • A0B · Phloxine B · ligand · chains A
  • NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · ligand · chains A
  • PO4 · Phosphate ion · ion · chains A
  • GOL · Glycerol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
14970.720.8144A0B, NAP

Compared structures

  • 5OOG · Human biliverdin IX beta reductase: NADP/PHLOXINE B ternary complex · the same entry in another collection · chain A against A, TM-score 1.00
  • P30043 · AlphaFold monomer V2.0 prediction for flavin reductase (NADPH) (P30043) · a predicted model of the same protein · chain A against A, TM-score 0.99

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