UniProt P30043
Flavin reductase (NADPH) (P30043)
Flavin reductase (NADPH) (UniProt P30043), EC 1.3.1.24, 1.5.1.30: 34 experimental structures and 1 predicted model on GenesisL1, 14 ligands bound, 20 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P30043
- Protein
- Flavin reductase (NADPH)
- EC
- 1.3.1.24, 1.5.1.30
- Experimental structures
- 34
- Predicted models
- 1
- Ligands
- 14
- Pockets
- 20 · 8 records with a druggable one
Structures
35 records of P30043 in the MolNFT archive: 34 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1HDO | Human biliverdin IX beta reductase: NADP complex | x-ray diffraction | A | — | — |
| 1HDO | Human biliverdin IX beta reductase: NADP complex | x-ray diffraction | A | — | — |
| 1HE2 | Human biliverdin IX beta reductase: NADP/biliverdin IX alpha ternary complex | x-ray diffraction | A | — | — |
| 1HE2 | Human biliverdin IX beta reductase: NADP/BILIVERDIN IX alpha ternary complex | x-ray diffraction | A | — | — |
| 1HE3 | Human biliverdin IX beta reductase: NADP/mesobiliverdin IV alpha ternary complex | x-ray diffraction | A | — | — |
| 1HE3 | Human biliverdin IX beta reductase: NADP/MESOBILIVERDIN IV alpha ternary complex | x-ray diffraction | A | — | — |
| 1HE4 | Human biliverdin IX beta reductase: NADP/FMN ternary complex | x-ray diffraction | A | — | — |
| 1HE4 | Human biliverdin IX beta reductase: NADP/FMN ternary complex | x-ray diffraction | A | — | — |
| 1HE5 | Human biliverdin IX beta reductase: NADP/Lumichrome ternary complex | x-ray diffraction | A | — | — |
| 1HE5 | Human biliverdin IX beta reductase: NADP/LUMICHROME ternary complex | x-ray diffraction | A | — | — |
| 5OOG | Human biliverdin IX beta reductase: NADP/Phloxine B ternary complex | x-ray diffraction | A | A0B, PO4, NAP | — |
| 5OOG | Human biliverdin IX beta reductase: NADP/PHLOXINE B ternary complex | x-ray diffraction | A | A0B, PO4, NAP | — |
| 5OOH | Human biliverdin IX beta reductase: NADP/Erythrosin extra bluish ternary complex | x-ray diffraction | A | NAP, 9ZZ | — |
| 5OOH | Human biliverdin IX beta reductase: NADP/ERYTHROSIN extra bluish ternary complex | x-ray diffraction | A | NAP, 9ZZ | — |
| 6OPL | Human biliverdin IX beta reductase Q14R mutant: NADP complex | x-ray diffraction | A | NAP | 1 (best 0.74) |
| 6OPL | Human biliverdin IX beta reductase Q14R mutant: NADP complex | x-ray diffraction | A | NAP | — |
| 7ER6 | Crystal structure of human Biliverdin IX-beta reductase B | x-ray diffraction | A, B | NAP, SO4 | 2 (best 0.82) |
| 7ER6 | Crystal structure of human biliverdin IX-beta reductase B | x-ray diffraction | A, B | NAP, SO4 | — |
| 7ER7 | Crystal structure of hyman Biliverdin IX-beta reductase B with Tamibarotene (A80) | x-ray diffraction | A, B | NAP, A80, SO4 | 2 (best 0.78) |
| 7ER7 | Crystal structure of hyman biliverdin IX-beta reductase B with tamibarotene (A80) | x-ray diffraction | A, B | NAP, A80, SO4 | — |
| 7ER8 | Crystal structure of human Biliverdin IX-beta reductase B with Sulfasalazine (SAS) | x-ray diffraction | A, B | NAP, SAS, SO4 | — |
| 7ER8 | Crystal structure of human biliverdin IX-beta reductase B with sulfasalazine (sas) | x-ray diffraction | A, B | NAP, SAS, SO4 | — |
| 7ER9 | Crystal structure of human Biliverdin IX-beta reductase B with Febuxostat (TEI) | x-ray diffraction | A, B | NAP, TEI, SO4 | 2 (best 0.83) |
| 7ER9 | Crystal structure of human biliverdin IX-beta reductase B with febuxostat (tei) | x-ray diffraction | A, B | NAP, TEI, SO4 | — |
| 7ERA | Crystal structure of human biliverdin IX-beta reductase B with olsalazine sodium (oss) | x-ray diffraction | A, B | NAP, JBC, SO4 | — |
| 7ERB | Crystal structure of human biliverdin IX-beta reductase B with ataluren (ptc) | x-ray diffraction | A, B, C, D | NAP, JBF, SO4 | — |
| 7ERC | Crystal structure of human Biliverdin IX-beta reductase B with Deferasirox (ICL) | x-ray diffraction | A, B | NAP, JBL, SO4 | 3 (best 0.81) |
| 7ERC | Crystal structure of human biliverdin IX-beta reductase B with deferasirox (icl) | x-ray diffraction | A, B | NAP, JBL, SO4 | — |
| 7ERD | Crystal structure of human Biliverdin IX-beta reductase B with Flunixin Meglumin (FMG) | x-ray diffraction | A, B | NAP, JBO, SO4 | 3 (best 0.82) |
| 7ERD | Crystal structure of human biliverdin IX-beta reductase B with flunixin meglumin (fmg) | x-ray diffraction | A, B | NAP, JBO, SO4 | — |
| 7ERE | Crystal structure of human Biliverdin IX-beta reductase B with Pyrantel Pamoate (PPA) | x-ray diffraction | A, B, C, D | NAP, JBR, SO4 | 6 (best 0.84) |
| 7ERE | Crystal structure of human biliverdin IX-beta reductase B with pyrantel pamoate (ppa) | x-ray diffraction | A, B, C, D | NAP, JBR, SO4 | — |
| 8ELL | Apo human biliverdin reductase beta (cryogenic) | x-ray diffraction | A | NA | 1 (best 0.70) |
| 8ELM | Apo human biliverdin reductase beta (293K) | x-ray diffraction | A | NA | — |
| P30043 | AlphaFold monomer V2.0 prediction for flavin reductase (NADPH) (P30043) | predicted | A | — | — |
Ligands
- NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · in 22 records
- SO4 · Sulfate ion · in 16 records
- 9ZZ · Erythrosin · in 2 records
- A0B · Phloxine B · in 2 records
- A80 · 4-[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbamoyl]benzoic acid · in 2 records
- JBL · 4-[3,5-bis(2-hydroxyphenyl)-1,2,4-triazol-1-yl]benzoic acid · in 2 records
- JBO · 2-[[2-methyl-3-(trifluoromethyl)phenyl]amino]pyridine-3-carboxylic acid · in 2 records
- JBR · 4-[(3-carboxy-2-oxidanyl-naphthalen-1-yl)methyl]-3-oxidanyl-naphthalene-2-carboxylic acid · in 2 records
- NA · Sodium ion · in 2 records
- PO4 · Phosphate ion · in 2 records
- SAS · 2-hydroxy-(5-([4-(2-pyridinylamino)sulfonyl]phenyl) azo)benzoic acid · in 2 records
- TEI · 2-(3-cyano-4-isobutoxy-phenyl)-4-methyl-5-thiazole-carboxylic acid · in 2 records
- JBC · 5-[(E)-(3-carboxy-4-oxidanyl-phenyl)diazenyl]-2-oxidanyl-benzoic acid · in 1 record
- JBF · 3-[5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl]benzoic acid · in 1 record
Experiment against prediction
- 7ER7 chain A against the predicted model P30043: TM-score 0.99, RMSD 0.63 Å
- 7ER7 chain A against the predicted model P30043: TM-score 0.99, RMSD 0.63 Å
- 8ELL chain A against the predicted model P30043: TM-score 0.99, RMSD 0.52 Å
- 1HE4 chain A against the predicted model P30043: TM-score 0.99, RMSD 0.63 Å
- 1HE4 chain A against the predicted model P30043: TM-score 0.99, RMSD 0.63 Å
- 1HE2 chain A against the predicted model P30043: TM-score 0.99, RMSD 0.64 Å
- 1HE2 chain A against the predicted model P30043: TM-score 0.99, RMSD 0.64 Å
- 1HE3 chain A against the predicted model P30043: TM-score 0.99, RMSD 0.64 Å
- 1HE3 chain A against the predicted model P30043: TM-score 0.99, RMSD 0.64 Å
- 5OOG chain A against the predicted model P30043: TM-score 0.99, RMSD 0.64 Å
Elsewhere
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