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MolNFT v1 · #129578 · protein

Human biliverdin IX beta reductase: NADP/PHLOXINE B ternary complex

5OOG · Flavin reductase (NADPH): “Human biliverdin IX beta reductase: NADP/PHLOXINE B ternary complex”. X-ray diffraction, 3 ligands (A0B, NAP, PO4), 1 pocket (best druggability 0.72). MolNFT v1 #129578 on GenesisL1: 3D structure, binding…

PDB
5OOG
Type
protein
Length
205 residues
Chains
1
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Flavin reductase (NADPH)
EC
1.5.1.30, 1.3.1.24
UniProt
P30043
Ligands
A0B, NAP, PO4
Pockets
1 · best druggability 0.72

Structure

x-ray diffraction · 1 distinct chain · 38% helix, 21% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
AFlavin reductase (NADPH) (EC 1.5.1.30, 1.3.1.24)protein20538% helix, 21% strandP30043

Ligands and binding sites

  • A0B · Phloxine B · ligand · chains A
  • NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · ligand · chains A
  • PO4 · Phosphate ion · ion · chains A
  • GOL · Glycerol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
14970.720.8144A0B, NAP

Compared structures

  • 5OOG · Human biliverdin IX beta reductase: NADP/Phloxine B ternary complex · the same entry in another collection · chain A against A, TM-score 1.00
  • P30043 · AlphaFold monomer V2.0 prediction for flavin reductase (NADPH) (P30043) · a predicted model of the same protein · chain A against A, TM-score 0.99

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