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Macrolide 2'-phosphotransferase type II - complex with GDP and phosphorylated josamycin

Analyse Macrolide 2'-phosphotransferase type II - complex with GDP and phosphorylated… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5IH1
Type: protein
Length: 297 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 1.31
Source: Escherichia coli
Molecule: Macrolide 2'-phosphotransferase II
UniProt: O32553
Ligands: GDP, 6BQ, MG, CA
Pockets: 1 · best druggability 0.74

Structure

x-ray diffraction · resolution 1.31 · 1 distinct chain · 49% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Macrolide 2'-phosphotransferase II	protein	297	49% helix, 16% strand	O32553

Ligands and binding sites

GDP · Guanosine-5'-diphosphate · ligand · chains A
6BQ · Phosphorylated josamycin · ligand · chains A
MG · Magnesium ion · metal · chains A
CA · Calcium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	909	0.74	0.77	74	GDP, MG, CA, 6BQ

Compared structures

5IH1 · Macrolide 2'-phosphotransferase type II - complex with GDP and phosphorylated josamycin · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O32553
Elsewhere: RCSB PDB 5IH1 · PDBe 5IH1 · UniProt O32553

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