Research workbench
S. enterica HisA mutant D10G, Dup13-15, Q24L, G102A, V106L
Analyse S. enterica HisA mutant D10G, Dup13-15, Q24L, G102A, V106L in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5G4E
- Type
- protein
- Length
- 426 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.65
- Source
- Salmonella enterica
- Molecule
- 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide…
- EC
- 5.3.1.16
- UniProt
- A0A630AQ07
- Ligands
- NA, SO4
- Pockets
- 3 · best druggability 0.75
Structure
x-ray diffraction · resolution 2.65 · 2 distinct chains · 43% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (EC 5.3.1.16) | protein | 220 | 41% helix, 26% strand | A0A630AQ07 |
| B | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (EC 5.3.1.16) | protein | 206 | 44% helix, 22% strand | A0A630AQ07 |
Ligands and binding sites
- NA · Sodium ion · metal · 4 copies · chains A, B
- SO4 · Sulfate ion · ion · 2 copies · chains A, B
- ACY · Acetic acid · additive · 2 copies · chains A, B
- GOL · Glycerol · additive · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 76 | 0.75 | 0.98 | 22 | empty |
| 2 | 498 | 0.74 | 0.83 | 44 | SO4 |
| 3 | 298 | 0.60 | 0.78 | 34 | SO4 |
Interfaces
1 interface between chains.
- A–B · 670 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 5G4E · S. enterica hisa mutant D10G, DUP13-15, Q24L, G102A, V106L · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A630AQ07
- Elsewhere: RCSB PDB 5G4E · PDBe 5G4E · UniProt A0A630AQ07
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