Research workbench
Structure of MAPK14 with bound the KIM domain of the Toxoplasma protein GRA24
Analyse Structure of MAPK14 with bound the KIM domain of the Toxoplasma protein GRA24 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5ETA
- Type
- protein
- Length
- 703 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.8
- Source
- Homo sapiens; SYNTHETIC CONSTRUCT
- Molecule
- Mitogen-activated protein kinase 14; Putative transmembrane protein
- EC
- 2.7.11.24
- UniProt
- Q16539, A0A086L2F3
- Pockets
- 13 · best druggability 0.68
Structure
x-ray diffraction · resolution 2.8 · 3 distinct chains · 40% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Mitogen-activated protein kinase 14 (EC 2.7.11.24) | protein | 335 | 40% helix, 16% strand | Q16539 |
| D, C | Putative transmembrane protein | protein | 16 | 25% helix, 0% strand | A0A086L2F3 |
| A | Mitogen-activated protein kinase 14 (EC 2.7.11.24) | protein | 336 | 41% helix, 16% strand | Q16539 |
Pockets
13 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 469 | 0.68 | 0.79 | 62 | empty |
| 2 | 355 | 0.64 | 0.79 | 44 | empty |
| 3 | 67 | 0.62 | 0.90 | 16 | empty |
| 4 | 212 | 0.52 | 0.77 | 33 | empty |
| 5 | 192 | 0.49 | 0.76 | 26 | empty |
Interfaces
6 interfaces between chains.
- A–C · 838 Ų buried · 11 hydrogen bonds · protein-protein
- B–D · 808 Ų buried · 14 hydrogen bonds · protein-protein
- B–A · 215 Ų buried · 2 hydrogen bonds · protein-protein
- B–C · 56 Ų buried · 0 hydrogen bonds · protein-protein
- D–C · 52 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 5ETA · Structure of MAPK14 with bound the kim domain of the toxoplasma protein GRA24 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q16539
- Every structure of UniProt A0A086L2F3
- Elsewhere: RCSB PDB 5ETA · PDBe 5ETA · UniProt Q16539 · UniProt A0A086L2F3
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