MolNFT v1 · #118150 · protein
Structure of MAPK14 with bound the kim domain of the toxoplasma protein GRA24
5ETA · Mitogen-activated protein kinase 14: “Structure of MAPK14 with bound the kim domain of the toxoplasma protein GRA24”. X-ray diffraction, 13 pockets (best druggability 0.68). MolNFT v1 #118150 on GenesisL1: 3D structure, binding…
- PDB
- 5ETA
- Type
- protein
- Length
- 703 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mitogen-activated protein kinase 14; Putative transmembrane protein
- EC
- 2.7.11.24
- UniProt
- Q16539, A0A086L2F3
- Pockets
- 13 · best druggability 0.68
Structure
x-ray diffraction · 3 distinct chains · 40% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Mitogen-activated protein kinase 14 (EC 2.7.11.24) | protein | 335 | 40% helix, 16% strand | Q16539 |
| D, C | Putative transmembrane protein | protein | 16 | 25% helix, 0% strand | A0A086L2F3 |
| A | Mitogen-activated protein kinase 14 (EC 2.7.11.24) | protein | 336 | 41% helix, 16% strand | Q16539 |
Pockets
13 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 469 | 0.68 | 0.79 | 62 | empty |
| 2 | 355 | 0.64 | 0.79 | 44 | empty |
| 3 | 67 | 0.62 | 0.90 | 16 | empty |
| 4 | 212 | 0.52 | 0.77 | 33 | empty |
| 5 | 192 | 0.49 | 0.76 | 26 | empty |
Interfaces
6 interfaces between chains.
- A–C · 838 Ų buried · 11 hydrogen bonds · protein-protein
- B–D · 808 Ų buried · 14 hydrogen bonds · protein-protein
- B–A · 215 Ų buried · 2 hydrogen bonds · protein-protein
- B–C · 56 Ų buried · 0 hydrogen bonds · protein-protein
- D–C · 52 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 5ETA · Structure of MAPK14 with bound the KIM domain of the Toxoplasma protein GRA24 · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q16539
- Every structure of UniProt A0A086L2F3
- Elsewhere: RCSB PDB 5ETA · PDBe 5ETA · UniProt Q16539 · UniProt A0A086L2F3
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