UniProt Q16539
Mitogen-activated protein kinase 14 (Q16539)
Mitogen-activated protein kinase 14 (UniProt Q16539), EC 2.7.11.24: 470 experimental structures on GenesisL1, 44 ligands bound, 22 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q16539
- Protein
- Mitogen-activated protein kinase 14
- EC
- 2.7.11.24
- Experimental structures
- 470
- Predicted models
- 0
- Ligands
- 44
- Pockets
- 22 · 5 records with a druggable one
Structures
470 records of Q16539 in the MolNFT archive: 470 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1A9U | The complex structure of the MAP kinase P38/SB203580 | x-ray diffraction | A | — | — |
| 1A9U | The complex structure of the MAP kinase P38/SB203580 | x-ray diffraction | A | — | — |
| 1BL6 | The complex structure of the MAP kinase P38/SB216995 | x-ray diffraction | A | — | — |
| 1BL6 | The complex structure of the MAP kinase P38/SB216995 | x-ray diffraction | A | — | — |
| 1BL7 | The complex structure of the MAP kinase P38/SB220025 | x-ray diffraction | A | — | — |
| 1BL7 | The complex structure of the MAP kinase P38/SB220025 | x-ray diffraction | A | — | — |
| 1BMK | The complex structure of the MAP kinase P38/SB218655 | x-ray diffraction | A | — | — |
| 1BMK | The complex structure of the MAP kinase P38/SB218655 | x-ray diffraction | A | — | — |
| 1DI9 | The structure of P38 mitogen-activated protein kinase in complex with… | x-ray diffraction | A | — | — |
| 1DI9 | The structure of P38 mitogen-activated protein kinase in complex with… | x-ray diffraction | A | — | — |
| 1IAN | Human P38 MAP kinase inhibitor complex | x-ray diffraction | A | — | — |
| 1IAN | Human P38 MAP kinase inhibitor complex | x-ray diffraction | A | — | — |
| 1KV1 | p38 MAP Kinase in Complex with Inhibitor 1 | x-ray diffraction | A | — | — |
| 1KV1 | P38 MAP kinase in complex with inhibitor 1 | x-ray diffraction | A | — | — |
| 1KV2 | Human p38 MAP Kinase in Complex with BIRB 796 | x-ray diffraction | A | — | — |
| 1KV2 | Human P38 MAP kinase in complex with birb 796 | x-ray diffraction | A | — | — |
| 1M7Q | Crystal structure of p38 MAP kinase in complex with a dihydroquinazoli inhibitor | x-ray diffraction | A | — | — |
| 1M7Q | Crystal structure of P38 MAP kinase in complex with a dihydroquinazolinone inhibitor | x-ray diffraction | A | — | — |
| 1OUK | The structure of p38 alpha in complex with a pyridinylimidazole inhibitor | x-ray diffraction | A | — | — |
| 1OUK | The structure of P38 alpha in complex with a pyridinylimidazole inhibitor | x-ray diffraction | A | — | — |
| 1OUY | The structure of p38 alpha in complex with a dihydropyrido-pyrimidine inhibitor | x-ray diffraction | A | — | — |
| 1OUY | The structure of P38 alpha in complex with a dihydropyrido-pyrimidine inhibitor | x-ray diffraction | A | — | — |
| 1OVE | The structure of p38 alpha in complex with a dihydroquinoli | x-ray diffraction | A | — | — |
| 1OVE | The structure of P38 alpha in complex with a dihydroquinolinone | x-ray diffraction | A | — | — |
| 1OZ1 | P38 mitogen-activated kinase in complex with 4-azaindole inhibitor | x-ray diffraction | A | — | — |
| 1OZ1 | P38 mitogen-activated kinase in complex with 4-azaindole inhibitor | x-ray diffraction | A | — | — |
| 1R39 | The structure of P38ALPHA | x-ray diffraction | A | — | — |
| 1R39 | The structure of P38ALPHA | x-ray diffraction | A | — | — |
| 1R3C | The structure of P38ALPHA C162S mutant | x-ray diffraction | A | — | — |
| 1R3C | The structure of P38ALPHA C162S mutant | x-ray diffraction | A | — | — |
| 1W7H | p38 Kinase crystal structure in complex with small molecule inhibitor | x-ray diffraction | A | — | — |
| 1W7H | P38 kinase crystal structure in complex with small molecule inhibitor | x-ray diffraction | A | — | — |
| 1W82 | p38 Kinase crystal structure in complex with small molecule inhibitor | x-ray diffraction | A | — | — |
| 1W82 | P38 kinase crystal structure in complex with small molecule inhibitor | x-ray diffraction | A | — | — |
| 1W83 | p38 Kinase crystal structure in complex with small molecule inhibitor | x-ray diffraction | A | — | — |
| 1W83 | P38 kinase crystal structure in complex with small molecule inhibitor | x-ray diffraction | A | — | — |
| 1W84 | p38 Kinase crystal structure in complex with small molecule inhibitor | x-ray diffraction | A | — | — |
| 1W84 | P38 kinase crystal structure in complex with small molecule inhibitor | x-ray diffraction | A | — | — |
| 1WBN | fragment based p38 inhibitors | x-ray diffraction | A | — | — |
| 1WBN | Fragment based P38 inhibitors | x-ray diffraction | A | — | — |
| 1WBO | fragment based p38 inhibitors | x-ray diffraction | A | — | — |
| 1WBO | Fragment based P38 inhibitors | x-ray diffraction | A | — | — |
| 1WBS | Identification of novel p38 alpha MAP Kinase inhibitors using fragment-based lead generation. | x-ray diffraction | A | — | — |
| 1WBS | Identification of novel P38 alpha MAP kinase inhibitors using fragment-based lead generation. | x-ray diffraction | A | — | — |
| 1WBT | Identification of novel p38 alpha MAP Kinase inhibitors using fragment-based lead generation. | x-ray diffraction | A | — | — |
| 1WBT | Identification of novel P38 alpha MAP kinase inhibitors using fragment-based lead generation. | x-ray diffraction | A | — | — |
| 1WBV | Identification of novel p38 alpha MAP Kinase inhibitors using fragment-based lead generation. | x-ray diffraction | A | — | — |
| 1WBV | Identification of novel P38 alpha MAP kinase inhibitors using fragment-based lead generation. | x-ray diffraction | A | — | — |
| 1WBW | Identification of novel p38 alpha MAP Kinase inhibitors using fragment-based lead generation. | x-ray diffraction | A | — | — |
| 1WBW | Identification of novel P38 alpha MAP kinase inhibitors using fragment-based lead generation. | x-ray diffraction | A | — | — |
| 1WFC | Structure of apo, unphosphorylated, P38 mitogen activated protein kinase P38 (P38 MAP kinase) the… | x-ray diffraction | A | — | — |
| 1WFC | Structure of apo, unphosphorylated, P38 mitogen activated protein kinase P38 (P38 MAP kinase) the… | x-ray diffraction | A | — | — |
| 1YQJ | Crystal Structure of p38 Alpha in Complex with a Selective Pyridazine Inhibitor | x-ray diffraction | A | — | — |
| 1YQJ | Crystal structure of P38 alpha in complex with a selective pyridazine inhibitor | x-ray diffraction | A | — | — |
| 1ZYJ | Human P38 MAP Kinase in Complex with Inhibitor 1a | x-ray diffraction | A | — | — |
| 1ZYJ | Human P38 MAP kinase in complex with inhibitor 1A | x-ray diffraction | A | — | — |
| 1ZZ2 | Two Classes of p38alpha MAP Kinase Inhibitors Having a Common Diphenylether Core but Exhibiting… | x-ray diffraction | A | — | — |
| 1ZZ2 | Two classes of P38ALPHA MAP kinase inhibitors having a common diphenylether core but exhibiting… | x-ray diffraction | A | — | — |
| 1ZZL | Crystal structure of P38 with triazolopyridine | x-ray diffraction | A | — | — |
| 1ZZL | Crystal structure of P38 with triazolopyridine | x-ray diffraction | A | — | — |
410 records more on the page itself.
Ligands
- 1VI · 3-(2,5-dimethoxyphenyl)-~{N}-[4-[4-(4-fluorophenyl)-2-methylsulfanyl-1~{H}-imidazol-5-yl]pyridin-2-yl]propanamide · in 2 records
- 39G · N-[5-(dimethylsulfamoyl)-2-methylphenyl]-1-phenyl-5-propyl-1H-pyrazole-4-carboxamide · in 2 records
- 8EN · ~{N}-[3-(2-acetamidoimidazo[1,2-a]pyridin-6-yl)-4-methyl-phenyl]-3-(trifluoromethyl)benzamide · in 2 records
- 8OK · 2-(4-morpholin-4-ylphenyl)-~{N}4-(2-phenylethyl) quinazoline-4,7-diamine · in 2 records
- 8OT · 2-phenyl-~{N}4-(2-thiophen-2-ylethyl)quinazoline-4,7-diamine · in 2 records
- 9O2 · ~{N}-[3-[7-azanyl-4-(2-phenylethylamino)quinazolin-2-yl]phenyl]propanamide · in 2 records
- 9Y5 · 1-(3-chlorophenyl)-3-methyl-4~{H}-pyrazolo[4,3-c][1,2]benzothiazine 5,5-dioxide · in 2 records
- 9Y8 · 3-(4-fluorophenyl)-4-methyl-1~{H}-pyrazolo[4,3-c][1,2]benzothiazine 5,5-dioxide · in 2 records
- B96 · 1-(5-tert-butyl-2-P-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea · in 2 records
- FJI · 3-[(3-benzamido-4-fluoranyl-phenyl)amino]-~{N}-(2-morpholin-4-ylethyl)-11-oxidanylidene-6~{H}-benzo[c][1]benzoxepine-9-carboxamide · in 2 records
- GEW · 3-(2,5-dimethoxyphenyl)-~{N}-[4-[5-(4-fluorophenyl)-2-[(~{E})-(4-fluorophenyl)diazenyl]-3-methyl-imidazol-4-yl]pyridin-2-yl]propanamide · in 2 records
- GXH · 3-(2,5-dimethoxyphenyl)-~{N}-[4-[4-(4-fluorophenyl)-2-(2-phenylhydrazinyl)-1,3-thiazol-5-yl]pyridin-2-yl]propanamide · in 2 records
- I46 · 2-fluoro-4-[4-(4-fluorophenyl)-1H-pyrazol-3-yl]pyridine · in 2 records
- J8S · (4-benzylpiperidin-1-yl)[2-methoxy-4-(methylsulfanyl) phenyl]methanone · in 2 records
- J9G · 3-benzyl-6-[(2,4-difluorophenyl)amino]-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one · in 2 records
- LB5 · ~{N}-[(2~{S})-1-azanyl-4-cyclohexyl-1-oxidanylidene-butan-2-yl]-2-[[[1-(2-methylphenyl)pyrazol-4-yl]carbonylamino]methyl]-1,3-thiazole-5-carboxamide · in 2 records
- LBE · 5-azanyl-~{N}-[[4-(3-cyclohexylpropylcarbamoyl) phenyl]methyl]-1-phenyl-pyrazole-4-carboxamide · in 2 records
- NA · Sodium ion · in 2 records
- SO4 · Sulfate ion · in 2 records
- 3FF · 2-[(2,4-difluorophenyl)amino]-7-{[(2R)-2,3-dihydroxypropyl]oxy}-10,11-dihydro-5H-dibenzo[a, d][7]annulen-5-one · in 1 record
- 78L · ~{N}-[2,4-bis(fluoranyl)-5-[[9-(2-morpholin-4-ylethylcarbamoyl)-11-oxidanylidene-5,6-dihydrodibenzo[1,2-~{D}:1',2'-~{f}][7]annulen-3-yl]amino]phenyl]thiophene-2-carboxamide · in 1 record
- 79Q · 3-[(3-benzamido-4-fluoranyl-phenyl)amino]-~{N}-(2-morpholin-4-ylethyl)-11-oxidanylidene-5,6-dihydrodibenzo[1,2-~{D}:1',2'-~{f}][7]annulene-9-carboxamide · in 1 record
- 8OH · 2-phenyl-~{N}4-(thiophen-2-ylmethyl)quinazoline-4,7-diamine · in 1 record
- 8ON · 1-[4-[4-[7-azanyl-4-(2-phenylethylamino)quinazolin-2-yl]phenyl]piperazin-1-yl]ethanone · in 1 record
- 8OW · ~{N}4-[(4-fluorophenyl)methyl]-2-phenyl-quinazoline-4, 7-diamine · in 1 record
- 9O5 · 4-[3-[7-azanyl-4-(2-phenylethylamino)quinazolin-2-yl]phenyl]butan-2-one · in 1 record
- AP2 · Phosphomethylphosphonic acid adenosyl ester · in 1 record
- AQY · N-{4-[2-(4-fluoro-3-methylphenyl)imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl}-2-methyl-1-oxo-1lambda~5~-pyridine-4-carboxamide · in 1 record
- BW1 · ~{N}4-[[4-(cyclopropylmethyl)furan-2-yl]methyl]-2-phenyl-quinazoline-4,7-diamine · in 1 record
- FTZ · N-(2-chloro-6-fluorobenzyl)-5-(furan-2-yl)-2H-1,2,4-triazol-3-amine · in 1 record
Experiment against prediction
- 6RFO chain A against the predicted model P63086: TM-score 0.98, RMSD 1.04 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.