mGluR3 complexed with glutamate analog

Structure

x-ray diffraction · resolution 2.84 · 1 distinct chain · 39% helix, 20% strand (DSSP).

Ligands and binding sites

• 52Q · (1R,2S,4R,5R,6R)-2-amino-4-(1H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic acid · ligand · chains A
• MG · Magnesium ion · metal · chains A
• CL · Chloride ion · ion · 2 copies · chains A
• SO4 · Sulfate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Modifications

Observed in the structure: 3 disulfide (disulfide).

Compared structures

• 5CNM · MGLUR3 complexed with glutamate analog · the same entry in another collection · chain A against A, TM-score 1.00
• Q14832 · AlphaFold monomer V2.0 prediction for metabotropic glutamate receptor 3 (Q14832) · a predicted model of the same protein · chain A against A, TM-score 0.86

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q14832
• Elsewhere: RCSB PDB 5CNM · PDBe 5CNM · UniProt Q14832