MolNFT v1 · #115567 · protein

MGLUR3 complexed with glutamate analog

5CNM · Metabotropic glutamate receptor 3: “MGLUR3 complexed with glutamate analog”. X-ray diffraction, 4 ligands (52Q, MG, CL), 3 pockets (best druggability 0.58). MolNFT v1 #115567 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 5CNM
Type: protein
Length: 434 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Metabotropic glutamate receptor 3
UniProt: Q14832
Ligands: 52Q, MG, CL, SO4
Pockets: 3 · best druggability 0.58

Structure

x-ray diffraction · 1 distinct chain · 39% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Metabotropic glutamate receptor 3	protein	434	39% helix, 20% strand	Q14832

Ligands and binding sites

52Q · (1R,2S,4R,5R,6R)-2-amino-4-(1H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic acid · ligand · chains A
MG · Magnesium ion · metal · chains A
CL · Chloride ion · ion · 2 copies · chains A
SO4 · Sulfate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	140	0.58	0.84	27	empty
2	286	0.55	0.76	33	52Q, CL
3	66	0.35	0.77	16	empty

Modifications

Observed in the structure: 3 disulfide (disulfide).

Compared structures

5CNM · mGluR3 complexed with glutamate analog · the same entry in another collection · chain A against A, TM-score 1.00
Q14832 · AlphaFold monomer V2.0 prediction for metabotropic glutamate receptor 3 (Q14832) · a predicted model of the same protein · chain A against A, TM-score 0.86

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q14832
Elsewhere: RCSB PDB 5CNM · PDBe 5CNM · UniProt Q14832

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