Research workbench
Crystal structure and charge density studies of cholesterol oxidase from Brevibacterium sterolicum at 0.74 ultra-high resolution
Analyse Crystal structure and charge density studies of cholesterol oxidase from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4REK
- Type
- protein
- Length
- 498 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 0.74
- Source
- Streptomyces sp.
- Molecule
- Cholesterol oxidase
- EC
- 1.1.3.6, 5.3.3.1
- UniProt
- P12676
- Ligands
- FAD, PO4
- Pockets
- 3 · best druggability 0.86
Structure
x-ray diffraction · resolution 0.74 · 1 distinct chain · 29% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cholesterol oxidase (EC 1.1.3.6, 5.3.3.1) | protein | 498 | 29% helix, 24% strand | P12676 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 669 | 0.86 | 0.90 | 86 | FAD |
| 2 | 174 | 0.56 | 0.81 | 36 | empty |
| 3 | 86 | 0.33 | 0.74 | 23 | empty |
Compared structures
- 4REK · Crystal structure and charge density studies of cholesterol oxidase from brevibacterium… · the same entry in another collection · chain A against A, TM-score 1.00
- P12676 · AlphaFold monomer V2.0 prediction for cholesterol oxidase (P12676) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P12676
- Elsewhere: RCSB PDB 4REK · PDBe 4REK · UniProt P12676
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