Research workbench
Structure of yeast importin a bound to the membrane protein Nuclear Localization Signal sequence of INM protein Heh2
Analyse Structure of yeast importin a bound to the membrane protein Nuclear… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4PVZ
- Type
- protein
- Length
- 898 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.5
- Source
- Saccharomyces cerevisiae S288c
- Molecule
- Importin subunit alpha; Inner nuclear membrane protein HEH2
- UniProt
- Q02821, Q03281
- Pockets
- 7 · best druggability 0.67
Structure
x-ray diffraction · resolution 2.5 · 3 distinct chains · 69% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Importin subunit alpha | protein | 422 | 75% helix, 0% strand | Q02821 |
| C | Inner nuclear membrane protein HEH2 | protein | 35 | 17% helix, 0% strand | Q03281 |
| D | Inner nuclear membrane protein HEH2 | protein | 19 | 21% helix, 0% strand | Q03281 |
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 677 | 0.67 | 0.76 | 60 | empty |
| 2 | 286 | 0.61 | 0.80 | 35 | empty |
| 3 | 330 | 0.56 | 0.76 | 28 | empty |
| 4 | 243 | 0.49 | 0.74 | 33 | empty |
| 5 | 116 | 0.42 | 0.77 | 24 | empty |
Interfaces
5 interfaces between chains.
- A–C · 1856 Ų buried · 46 hydrogen bonds · protein-protein
- B–D · 1563 Ų buried · 40 hydrogen bonds · protein-protein
- A–B · 838 Ų buried · 7 hydrogen bonds · protein-protein
- B–C · 245 Ų buried · 0 hydrogen bonds · protein-protein
- A–D · 46 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 4PVZ · Structure of yeast importin a bound to the membrane protein nuclear localization signal… · the same entry in another collection · chain A against A, TM-score 1.00
- Q02821 · AlphaFold monomer V2.0 prediction for importin subunit alpha (Q02821) · a predicted model of the same protein · chain A against A, TM-score 0.98
- Q03281 · AlphaFold monomer V2.0 prediction for inner nuclear membrane protein HEH2 (Q03281) · a predicted model of the same protein · chain C against A, TM-score 0.37
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q02821
- Every structure of UniProt Q03281
- Elsewhere: RCSB PDB 4PVZ · PDBe 4PVZ · UniProt Q02821 · UniProt Q03281
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