MolNFT v1 · #103946 · protein

Structure of yeast importin a bound to the membrane protein nuclear localization signal sequence of inm protein HEH2

4PVZ · Importin subunit alpha: “Structure of yeast importin a bound to the membrane protein nuclear localization signal sequence of inm…”. X-ray diffraction, 7 pockets (best druggability 0.67). MolNFT v1 #103946 on GenesisL1: 3D structure…

PDB: 4PVZ
Type: protein
Length: 898 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Importin subunit alpha; Inner nuclear membrane protein HEH2
UniProt: Q02821, Q03281
Pockets: 7 · best druggability 0.67

Structure

x-ray diffraction · 3 distinct chains · 69% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Importin subunit alpha	protein	422	75% helix, 0% strand	Q02821
C	Inner nuclear membrane protein HEH2	protein	35	17% helix, 0% strand	Q03281
D	Inner nuclear membrane protein HEH2	protein	19	21% helix, 0% strand	Q03281

Pockets

7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	677	0.67	0.76	60	empty
2	286	0.61	0.80	35	empty
3	330	0.56	0.76	28	empty
4	243	0.49	0.74	33	empty
5	116	0.42	0.77	24	empty

Interfaces

5 interfaces between chains.

A–C · 1856 Å² buried · 46 hydrogen bonds · protein-protein
B–D · 1563 Å² buried · 40 hydrogen bonds · protein-protein
A–B · 838 Å² buried · 7 hydrogen bonds · protein-protein
B–C · 245 Å² buried · 0 hydrogen bonds · protein-protein
A–D · 46 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

4PVZ · Structure of yeast importin a bound to the membrane protein Nuclear Localization Signal… · the same entry in another collection · chain A against A, TM-score 1.00
Q02821 · AlphaFold monomer V2.0 prediction for importin subunit alpha (Q02821) · a predicted model of the same protein · chain A against A, TM-score 0.98
Q03281 · AlphaFold monomer V2.0 prediction for inner nuclear membrane protein HEH2 (Q03281) · a predicted model of the same protein · chain C against A, TM-score 0.37

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q02821
Every structure of UniProt Q03281
Elsewhere: RCSB PDB 4PVZ · PDBe 4PVZ · UniProt Q02821 · UniProt Q03281

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