Research workbench
AlphaFold monomer V2.0 prediction for carbon monoxide DEHYDROGENASE/ACETYL-CoA synthase subunit alpha (P27988)
Analyse AlphaFold monomer V2.0 prediction for carbon monoxide DEHYDROGENASE/ACETYL-CoA… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- P27988
- Type
- protein
- Length
- 729 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x5c4adF1416281C09AE8eE1cbb80fF7e44cE86F97
- Molecule
- Carbon monoxide DEHYDROGENASE/ACETYL-CoA synthase subunit alpha
- UniProt
- P27988
- Pockets
- 7 · best druggability 0.76
Structure
1 distinct chain · 44% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Carbon monoxide DEHYDROGENASE/ACETYL-CoA synthase subunit alpha | protein | 729 | 44% helix, 16% strand | P27988 |
Pockets
7 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 100 | 0.76 | 0.96 | 29 | empty |
| 2 | 430 | 0.72 | 0.83 | 40 | empty |
| 3 | 668 | 0.71 | 0.79 | 58 | empty |
| 4 | 275 | 0.57 | 0.77 | 36 | empty |
| 5 | 62 | 0.52 | 0.87 | 22 | empty |
Compared structures
- 2Z8Y · Xenon-bound structure of bifunctional carbon monoxide dehydrogenase/acetyl-CoA… · an experimental structure of the same protein · chain A against P, TM-score 0.78
- 2Z8Y · Xenon-bound structure of bifunctional carbon monoxide DEHYDROGENASE/ACETYL-CoA… · an experimental structure of the same protein · chain A against P, TM-score 0.78
- 3I04 · Cyanide-bound structure of bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase… · an experimental structure of the same protein · chain A against P, TM-score 0.78
- 3I04 · Cyanide-bound structure of bifunctional carbon monoxide DEHYDROGENASE/ACETYL-CoA synthase… · an experimental structure of the same protein · chain A against P, TM-score 0.78
- 1MJG · Crystal structure of bifunctional carbon monoxide DEHYDROGENASE/ACETYL-CoA… · an experimental structure of the same protein · chain A against P, TM-score 0.78
- 1MJG · Crystal structure of bifunctional carbon monoxide DEHYDROGENASE/ACETYL-CoA… · an experimental structure of the same protein · chain A against P, TM-score 0.78
- 3I01 · Native structure of bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase from… · an experimental structure of the same protein · chain A against P, TM-score 0.78
- 3I01 · Native structure of bifunctional carbon monoxide DEHYDROGENASE/ACETYL- CoA synthase from… · an experimental structure of the same protein · chain A against P, TM-score 0.78
- 6X5K · Crystal structure of CODH/ACS with carbon monoxide bound to the a- cluster · an experimental structure of the same protein · chain A against O, TM-score 0.78
- 6X5K · Crystal structure of CODH/ACS with carbon monoxide bound to the A-cluster · an experimental structure of the same protein · chain A against O, TM-score 0.78
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P27988
- Elsewhere: UniProt P27988 · AlphaFold DB P27988
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