UniProt P27988
Carbon monoxide dehydrogenase/acetyl-CoA synthase subunit alpha (P27988)
Carbon monoxide dehydrogenase/acetyl-CoA synthase subunit alpha (UniProt P27988), EC 2.3.1.169: 20 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 23 pockets. Binding sites, druggability and…
- UniProt
- P27988
- Protein
- Carbon monoxide dehydrogenase/acetyl-CoA synthase subunit alpha
- EC
- 2.3.1.169
- Experimental structures
- 20
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 23 · 2 records with a druggable one
Structures
21 records of P27988 in the MolNFT archive: 20 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1MJG | Crystal structure of bifunctional carbon monoxide DEHYDROGENASE/ACETYL-CoA SYNTHASE(CODH/ACS) from… | x-ray diffraction | M, N, O, P | — | — |
| 1MJG | Crystal structure of bifunctional carbon monoxide DEHYDROGENASE/ACETYL-CoA SYNTHASE(CODH/ACS) from… | x-ray diffraction | M, N, O, P | — | — |
| 1OAO | NiZn[Fe4S4] and NiNi[Fe4S4] clusters in closed and open alpha subunits of acetyl-CoA… | x-ray diffraction | C, D | — | — |
| 1OAO | NIZN[FE4S4] and NINI[FE4S4] clusters in closed and open alpha subunits of acetyl-CoA… | x-ray diffraction | C, D | — | — |
| 2Z8Y | Xenon-bound structure of bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase(CODH/ACS)… | x-ray diffraction | M, N, O, P | — | — |
| 2Z8Y | Xenon-bound structure of bifunctional carbon monoxide DEHYDROGENASE/ACETYL-CoA SYNTHASE(CODH/ACS)… | x-ray diffraction | M, N, O, P | — | — |
| 3GIT | Crystal structure of a truncated acetyl-CoA synthase | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3GIT | Crystal structure of a truncated acetyl-CoA synthase | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3I01 | Native structure of bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase from Moorella… | x-ray diffraction | M, N, O, P | — | — |
| 3I01 | Native structure of bifunctional carbon monoxide DEHYDROGENASE/ACETYL- CoA synthase from moorella… | x-ray diffraction | M, N, O, P | — | — |
| 3I04 | Cyanide-bound structure of bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase from… | x-ray diffraction | M, N, O, P | — | — |
| 3I04 | Cyanide-bound structure of bifunctional carbon monoxide DEHYDROGENASE/ACETYL-CoA synthase from… | x-ray diffraction | M, N, O, P | — | — |
| 3S2X | Structure of acetyl-Coenzyme A synthase Alpha subunit C-terminal domain | x-ray diffraction | A, B | — | — |
| 3S2X | Structure of acetyl-coenzyme a synthase alpha subunit C-terminal domain | x-ray diffraction | A, B | — | — |
| 5GOL | Structure of acetyl-Coenzyme A synthase Alpha subunit C-terminal domain F598H mutant | x-ray diffraction | A, B, C, D | SO4, NI | — |
| 5GOL | Structure of acetyl-coenzyme a synthase alpha subunit C-terminal domain F598H mutant | x-ray diffraction | A, B, C, D | — | — |
| 5H6W | Structure of acetyl-Coenzyme A synthase Alpha subunit C-terminal domain F598H mutant | x-ray diffraction | A, B, C, D | — | 4 (best 0.66) |
| 5H6W | Structure of acetyl-coenzyme a synthase alpha subunit C-terminal domain F598H mutant | x-ray diffraction | A, B, C, D | — | — |
| 6X5K | Crystal structure of CODH/ACS with carbon monoxide bound to the A-cluster | x-ray diffraction | M, N, O, P | SF4, NI, CMO, MG | 19 (best 0.87) |
| 6X5K | Crystal structure of CODH/ACS with carbon monoxide bound to the a- cluster | x-ray diffraction | M, N, O, P | SF4, NI, CMO, MG | — |
| P27988 | AlphaFold monomer V2.0 prediction for carbon monoxide DEHYDROGENASE/ACETYL-CoA synthase subunit… | predicted | A | — | — |
Ligands
Experiment against prediction
- 5H6W chain C against the predicted model P27988: TM-score 0.99, RMSD 0.40 Å
- 5H6W chain C against the predicted model P27988: TM-score 0.99, RMSD 0.40 Å
- 5H6W chain A against the predicted model P27988: TM-score 0.99, RMSD 0.41 Å
- 5H6W chain A against the predicted model P27988: TM-score 0.99, RMSD 0.41 Å
- 5H6W chain B against the predicted model P27988: TM-score 0.99, RMSD 0.47 Å
- 5H6W chain B against the predicted model P27988: TM-score 0.99, RMSD 0.47 Å
- 5H6W chain D against the predicted model P27988: TM-score 0.99, RMSD 0.48 Å
- 5H6W chain D against the predicted model P27988: TM-score 0.99, RMSD 0.48 Å
- 3S2X chain A against the predicted model P27988: TM-score 0.98, RMSD 0.65 Å
- 3S2X chain A against the predicted model P27988: TM-score 0.98, RMSD 0.65 Å
Elsewhere
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