Research workbench
AlphaFold monomer V2.0 prediction for tight junction protein zo-1 (Q07157)
Analyse AlphaFold monomer V2.0 prediction for tight junction protein zo-1 (Q07157) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- Q07157
- Type
- protein
- Length
- 1,748 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x98e22253e31B07cB0618d7388D8e56673A1A11dF
- Molecule
- Tight junction protein zo-1
- UniProt
- Q07157
- Pockets
- 11 · best druggability 0.78
Structure
1 distinct chain · 11% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tight junction protein zo-1 | protein | 1748 | 11% helix, 13% strand | Q07157 |
Pockets
11 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1183 | 0.78 | 0.80 | 88 | empty |
| 2 | 355 | 0.58 | 0.76 | 33 | empty |
| 3 | 295 | 0.58 | 0.77 | 43 | empty |
| 4 | 132 | 0.57 | 0.83 | 14 | empty |
| 5 | 155 | 0.41 | 0.74 | 26 | empty |
Compared structures
- 3TSZ · crystal structure of PDZ3-SH3-GUK core module from human ZO-1 in complex with 12mer… · an experimental structure of the same protein · chain A against A, TM-score 0.19
- 3TSZ · Crystal structure of PDZ3-SH3-guk core module from human zo-1 in complex with 12MER… · an experimental structure of the same protein · chain A against A, TM-score 0.19
- 3SHW · Crystal structure of zo-1 PDZ3-SH3-guk supramodule complex with connexin-45 peptide · an experimental structure of the same protein · chain A against A, TM-score 0.19
- 3SHW · Crystal structure of ZO-1 PDZ3-SH3-Guk supramodule complex with Connexin-45 peptide · an experimental structure of the same protein · chain A against A, TM-score 0.19
- 3TSW · Crystal structure of the PDZ3-SH3-guk core module of human zo-1 · an experimental structure of the same protein · chain A against C, TM-score 0.18
- 3TSW · crystal structure of the PDZ3-SH3-GUK core module of Human ZO-1 · an experimental structure of the same protein · chain A against C, TM-score 0.18
- 3LH5 · Crystal structure of the SH3-guanylate kinase core domain of zo-1 · an experimental structure of the same protein · chain A against A, TM-score 0.14
- 3LH5 · Crystal Structure of the SH3-Guanylate kinase core domain of ZO-1 · an experimental structure of the same protein · chain A against A, TM-score 0.14
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q07157
- Elsewhere: UniProt Q07157 · AlphaFold DB Q07157
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