MolNFT v1 · #70324 · protein
Crystal structure of the SH3-guanylate kinase core domain of zo-1
3LH5 · Tight junction protein zo-1: “Crystal structure of the SH3-guanylate kinase core domain of zo-1”. X-ray diffraction, 2 pockets (best druggability 0.73). MolNFT v1 #70324 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3LH5
- Type
- protein
- Length
- 248 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tight junction protein zo-1
- UniProt
- Q07157
- Pockets
- 2 · best druggability 0.73
Structure
x-ray diffraction · 1 distinct chain · 33% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tight junction protein zo-1 | protein | 248 | 33% helix, 25% strand | Q07157 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 524 | 0.73 | 0.81 | 43 | empty |
| 2 | 182 | 0.50 | 0.77 | 21 | empty |
Compared structures
- 3LH5 · Crystal Structure of the SH3-Guanylate kinase core domain of ZO-1 · the same entry in another collection · chain A against A, TM-score 1.00
- Q07157 · AlphaFold monomer V2.0 prediction for tight junction protein zo-1 (Q07157) · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q07157
- Elsewhere: RCSB PDB 3LH5 · PDBe 3LH5 · UniProt Q07157
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