UniProt Q07157
Tight junction protein ZO-1 (Q07157)
Tight junction protein ZO-1 (UniProt Q07157): 36 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 89 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q07157
- Protein
- Tight junction protein ZO-1
- Experimental structures
- 36
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 89 · 13 records with a druggable one
Structures
37 records of Q07157 in the MolNFT archive: 36 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2H2B | Crystal Structure of ZO-1 PDZ1 Bound to a Phage-Derived Ligand (WRRTTYL) | x-ray diffraction | A | — | — |
| 2H2B | Crystal structure of zo-1 PDZ1 bound to a phage-derived ligand (wrrttyl) | x-ray diffraction | A | — | — |
| 2H2C | Crystal Structure of ZO-1 PDZ1 Bound to a Phage-Derived Ligand (WRRTTWV) | x-ray diffraction | A | — | 1 (best 0.33) |
| 2H2C | Crystal structure of zo-1 PDZ1 bound to a phage-derived ligand (wrrttwv) | x-ray diffraction | A | — | 1 (best 0.33) |
| 2H3M | Crystal Structure of ZO-1 PDZ1 | x-ray diffraction | A | SO4 | — |
| 2H3M | Crystal structure of zo-1 PDZ1 | x-ray diffraction | A | SO4 | — |
| 2JWE | Solution structure of the second PDZ domain from human zonula occludens-1: A dimeric form with 3D… | solution nmr | A, B | — | 1 (best 0.45) |
| 2JWE | Solution structure of the second PDZ domain from human zonula occludens-1: a dimeric form with 3D… | solution nmr | A, B | — | 1 (best 0.45) |
| 2KXR | ZO1 ZU5 domain MC/AA mutation | solution nmr | A | — | — |
| 2KXR | ZO1 ZU5 domain MC/AA mutation | solution nmr | A | — | — |
| 2KXS | ZO1 ZU5 domain in complex with GRINL1A peptide | solution nmr | A | — | 1 (best 0.36) |
| 2KXS | ZO1 ZU5 domain in complex with GRINL1A peptide | solution nmr | A | — | 1 (best 0.36) |
| 2RCZ | Structure of the second PDZ domain of ZO-1 | x-ray diffraction | A, B | — | 1 (best 0.27) |
| 2RCZ | Structure of the second PDZ domain of zo-1 | x-ray diffraction | A, B | — | 1 (best 0.27) |
| 3CYY | The crystal structure of ZO-1 PDZ2 in complex with the Cx43 peptide | x-ray diffraction | A, B | — | 1 (best 0.29) |
| 3CYY | The crystal structure of zo-1 PDZ2 in complex with the CX43 peptide | x-ray diffraction | A, B | — | 1 (best 0.29) |
| 3LH5 | Crystal Structure of the SH3-Guanylate kinase core domain of ZO-1 | x-ray diffraction | A | — | 2 (best 0.73) |
| 3LH5 | Crystal structure of the SH3-guanylate kinase core domain of zo-1 | x-ray diffraction | A | — | 2 (best 0.73) |
| 3SHU | Crystal structure of ZO-1 PDZ3 | x-ray diffraction | A, B | — | — |
| 3SHU | Crystal structure of zo-1 PDZ3 | x-ray diffraction | A, B | — | — |
| 3SHW | Crystal structure of ZO-1 PDZ3-SH3-Guk supramodule complex with Connexin-45 peptide | x-ray diffraction | A | — | 3 (best 0.74) |
| 3SHW | Crystal structure of zo-1 PDZ3-SH3-guk supramodule complex with connexin-45 peptide | x-ray diffraction | A | — | 3 (best 0.74) |
| 3TSV | crystal structure of the third PDZ domain of the human ZO-1 MAGUK protein | x-ray diffraction | A | — | — |
| 3TSV | Crystal structure of the third PDZ domain of the human zo-1 maguk protein | x-ray diffraction | A | — | — |
| 3TSW | crystal structure of the PDZ3-SH3-GUK core module of Human ZO-1 | x-ray diffraction | A, B, C, D | SO4 | 19 (best 0.83) |
| 3TSW | Crystal structure of the PDZ3-SH3-guk core module of human zo-1 | x-ray diffraction | A, B, C, D | SO4 | 19 (best 0.83) |
| 3TSZ | crystal structure of PDZ3-SH3-GUK core module from human ZO-1 in complex with 12mer peptide from… | x-ray diffraction | A | — | 3 (best 0.66) |
| 3TSZ | Crystal structure of PDZ3-SH3-guk core module from human zo-1 in complex with 12MER peptide from… | x-ray diffraction | A | — | 3 (best 0.66) |
| 4OEO | High resolution crystal structure of the unliganded ZO-1 PDZ1 domain | x-ray diffraction | A, B, C | SO4 | 2 (best 0.71) |
| 4OEO | High resolution crystal structure of the unliganded zo-1 PDZ1 domain | x-ray diffraction | A, B, C | SO4 | 2 (best 0.71) |
| 4OEP | Crystal structure of the ZO-1 PDZ1 domain in complex with the 7-mer Claudin1 C-terminal tail | x-ray diffraction | A, B | — | 2 (best 0.73) |
| 4OEP | Crystal structure of the zo-1 PDZ1 domain in complex with the 7-mer CLAUDIN1 C-terminal tail | x-ray diffraction | A, B | — | 2 (best 0.73) |
| 4Q2Q | ZO1 PDZ3 in Complex with a Phage-Derived Peptide | x-ray diffraction | A | — | — |
| 4Q2Q | ZO1 PDZ3 in complex with a phage-derived peptide | x-ray diffraction | A | — | — |
| 4YYX | Crystal structure of the ZO-1 PDZ1 domain in complex with the 7-mer Claudin2 C-terminal tail | x-ray diffraction | A, B | — | 3 (best 0.32) |
| 4YYX | Crystal structure of the zo-1 PDZ1 domain in complex with the 7-mer CLAUDIN2 C-terminal tail | x-ray diffraction | A, B | — | 3 (best 0.32) |
| Q07157 | AlphaFold monomer V2.0 prediction for tight junction protein zo-1 (Q07157) | predicted | A | — | 11 (best 0.78) |
Ligands
- SO4 · Sulfate ion · in 6 records
Experiment against prediction
- 3SHW chain A against the predicted model Q07157: TM-score 0.98, RMSD 0.86 Å
- 3SHW chain A against the predicted model Q07157: TM-score 0.98, RMSD 0.86 Å
- 3TSZ chain A against the predicted model Q07157: TM-score 0.98, RMSD 1.16 Å
- 3TSZ chain A against the predicted model Q07157: TM-score 0.98, RMSD 1.16 Å
- 3TSV chain A against the predicted model Q07157: TM-score 0.97, RMSD 0.99 Å
- 3TSV chain A against the predicted model Q07157: TM-score 0.97, RMSD 0.99 Å
- 3LH5 chain A against the predicted model Q07157: TM-score 0.95, RMSD 1.85 Å
- 3LH5 chain A against the predicted model Q07157: TM-score 0.95, RMSD 1.85 Å
- 3SHU chain A against the predicted model Q07157: TM-score 0.95, RMSD 1.18 Å
- 3SHU chain A against the predicted model Q07157: TM-score 0.95, RMSD 1.18 Å
Elsewhere
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