MolNFT v1 · #42924 · protein

ZO1 ZU5 domain in complex with GRINL1A peptide

2KXS · Tight junction protein zo-1, linker, peptide of myocardium…: “ZO1 ZU5 domain in complex with GRINL1A peptide”. Solution nmr, 1 pocket (best druggability 0.36). MolNFT v1 #42924 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 2KXS
Type: protein
Length: 146 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tight junction protein zo-1, linker, peptide of myocardium- enriched zo-associated protein
UniProt: Q07157, D2E9U7
Pockets: 1 · best druggability 0.36

Structure

solution nmr · 1 distinct chain · 3% helix, 44% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tight junction protein zo-1, linker, peptide of myocardium- enriched zo-associated protein	protein	146	3% helix, 44% strand	Q07157, D2E9U7

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	113	0.36	0.73	19	empty

Compared structures

2KXS · ZO1 ZU5 domain in complex with GRINL1A peptide · the same entry in another collection · chain A against A, TM-score 1.00
Q07157 · AlphaFold monomer V2.0 prediction for tight junction protein zo-1 (Q07157) · a predicted model of the same protein · chain A against A, TM-score 0.64

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q07157
Every structure of UniProt D2E9U7
Elsewhere: RCSB PDB 2KXS · PDBe 2KXS · UniProt Q07157 · UniProt D2E9U7

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