MolNFT v1 · #38570 · protein

Crystal structure of zo-1 PDZ1 bound to a phage-derived ligand (wrrttwv)

2H2C · Tight junction protein zo-1: “Crystal structure of zo-1 PDZ1 bound to a phage-derived ligand (wrrttwv)”. X-ray diffraction, 1 pocket (best druggability 0.33). MolNFT v1 #38570 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 2H2C
Type: protein
Length: 107 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tight junction protein zo-1
UniProt: Q07157
Pockets: 1 · best druggability 0.33

Structure

x-ray diffraction · 1 distinct chain · 8% helix, 41% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tight junction protein zo-1	protein	107	8% helix, 41% strand	Q07157

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	84	0.33	0.74	19	empty

Compared structures

2H2C · Crystal Structure of ZO-1 PDZ1 Bound to a Phage-Derived Ligand (WRRTTWV) · the same entry in another collection · chain A against A, TM-score 1.00
Q07157 · AlphaFold monomer V2.0 prediction for tight junction protein zo-1 (Q07157) · a predicted model of the same protein · chain A against A, TM-score 0.88

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q07157
Elsewhere: RCSB PDB 2H2C · PDBe 2H2C · UniProt Q07157

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