Research workbench
AlphaFold monomer V2.0 prediction for son of sevenless homolog 2 (Q07890)
Analyse AlphaFold monomer V2.0 prediction for son of sevenless homolog 2 (Q07890) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- Q07890
- Type
- protein
- Length
- 1,332 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xB6aE45B1399Ef638D7fe596FD0B94A55c207203e
- Molecule
- Son of sevenless homolog 2
- UniProt
- Q07890
- Pockets
- 15 · best druggability 0.85
Structure
1 distinct chain · 45% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Son of sevenless homolog 2 | protein | 1332 | 45% helix, 6% strand | Q07890 |
Pockets
15 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 780 | 0.85 | 0.87 | 64 | empty |
| 2 | 1021 | 0.76 | 0.78 | 62 | empty |
| 3 | 140 | 0.69 | 0.89 | 30 | empty |
| 4 | 350 | 0.68 | 0.81 | 34 | empty |
| 5 | 147 | 0.61 | 0.84 | 23 | empty |
Compared structures
- 8UC9 · SOS2 co-crystal structure with fragment bound (compound 9) · an experimental structure of the same protein · chain A against A, TM-score 0.34
- 8T5M · SOS2 crystal structure with fragment bound (compound 14) · an experimental structure of the same protein · chain A against A, TM-score 0.33
- 8T5G · SOS2 co-crystal structure with fragment bound (compound 12) · an experimental structure of the same protein · chain A against A, TM-score 0.33
- 8T5R · SOS2 crystal structure with fragment bound (compound 13) · an experimental structure of the same protein · chain A against A, TM-score 0.33
- 6EIE · RAS guanine nucleotide exchange factor SOS2 (rem-CDC25), with surface mutations · an experimental structure of the same protein · chain A against A, TM-score 0.32
- 6EIE · Ras guanine nucleotide exchange factor SOS2 (Rem-cdc25), with surface mutations · an experimental structure of the same protein · chain A against A, TM-score 0.32
- 8UF2 · Apo SOS2 crystal structure in P1 space group · an experimental structure of the same protein · chain A against A, TM-score 0.32
- 8UH0 · SOS2 co-crystal structure with fragment bound (compound 10) · an experimental structure of the same protein · chain A against A, TM-score 0.32
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q07890
- Elsewhere: UniProt Q07890 · AlphaFold DB Q07890
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