UniProt Q07890
Son of sevenless homolog 2 (Q07890)
Son of sevenless homolog 2 (UniProt Q07890): 4 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 29 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q07890
- Protein
- Son of sevenless homolog 2
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 29 · 1 record with a druggable one
Structures
5 records of Q07890 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6EIE | RAS guanine nucleotide exchange factor SOS2 (rem-CDC25), with surface mutations | x-ray diffraction | A | — | — |
| 8T5G | SOS2 co-crystal structure with fragment bound (compound 12) | x-ray diffraction | A | SO4, THA | 4 (best 0.43) |
| 8T5M | SOS2 crystal structure with fragment bound (compound 14) | x-ray diffraction | A | SO4, YIF | 5 (best 0.43) |
| 8UH0 | SOS2 co-crystal structure with fragment bound (compound 10) | x-ray diffraction | A | WRN | 5 (best 0.41) |
| Q07890 | AlphaFold monomer V2.0 prediction for son of sevenless homolog 2 (Q07890) | predicted | A | — | 15 (best 0.85) |
Ligands
Experiment against prediction
- 8UH0 chain A against the predicted model Q07890: TM-score 0.93, RMSD 2.07 Å
- 8T5M chain A against the predicted model Q07890: TM-score 0.92, RMSD 2.49 Å
- 8T5G chain A against the predicted model Q07890: TM-score 0.92, RMSD 2.51 Å
- 6EIE chain A against the predicted model Q07890: TM-score 0.90, RMSD 2.83 Å
Elsewhere
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