Research workbench
AlphaFold monomer V2.0 prediction for son of sevenless homolog 1 (Q07889)
Analyse AlphaFold monomer V2.0 prediction for son of sevenless homolog 1 (Q07889) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- Q07889
- Type
- protein
- Length
- 1,333 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x71112d4fF7ebb3b617963c05f052289e073082FD
- Molecule
- Son of sevenless homolog 1
- UniProt
- Q07889
- Pockets
- 13 · best druggability 0.86
Structure
1 distinct chain · 47% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Son of sevenless homolog 1 | protein | 1333 | 47% helix, 5% strand | Q07889 |
Pockets
13 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 943 | 0.86 | 0.88 | 105 | empty |
| 2 | 706 | 0.70 | 0.77 | 50 | empty |
| 3 | 148 | 0.65 | 0.87 | 33 | empty |
| 4 | 168 | 0.61 | 0.84 | 22 | empty |
| 5 | 328 | 0.57 | 0.76 | 39 | empty |
Compared structures
- 3KSY · Crystal structure of the Histone domain, DH-PH unit, and catalytic unit of the Ras… · an experimental structure of the same protein · chain A against A, TM-score 0.74
- 3KSY · Crystal structure of the histone domain, dh-pH unit, and catalytic unit of the RAS… · an experimental structure of the same protein · chain A against A, TM-score 0.74
- 1XDV · Experimentally phased structure of human the son of sevenless protein at 4.1 ang. · an experimental structure of the same protein · chain A against B, TM-score 0.55
- 1XDV · Experimentally Phased Structure of Human the Son of Sevenless protein at 4.1 Ang. · an experimental structure of the same protein · chain A against B, TM-score 0.55
- 1XD4 · Crystal structure of the DH-PH-cat module of Son of Sevenless (SOS) · an experimental structure of the same protein · chain A against A, TM-score 0.52
- 1XD4 · Crystal structure of the dh-pH-cat module of son of sevenless (sos) · an experimental structure of the same protein · chain A against A, TM-score 0.52
- 7AVI · Crystal structure of SOS1 in complex with compound 2 · an experimental structure of the same protein · chain A against B, TM-score 0.35
- 5OVF · RAS guanine nucleotide exchange factor SOS1 (rem-CDC25) in complex with small molecule… · an experimental structure of the same protein · chain A against A, TM-score 0.35
- 5OVF · Ras guanine nucleotide exchange factor SOS1 (Rem-cdc25) in complex with small molecule… · an experimental structure of the same protein · chain A against A, TM-score 0.35
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q07889
- Elsewhere: UniProt Q07889 · AlphaFold DB Q07889
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