MolNFT v1 · #27241 · protein
Experimentally phased structure of human the son of sevenless protein at 4.1 ang.
1XDV · Son of sevenless protein homolog 1: “Experimentally phased structure of human the son of sevenless protein at 4.1 ang.”. X-ray diffraction, 20 pockets (best druggability 0.82). MolNFT v1 #27241 on GenesisL1: 3D structure, binding…
- PDB
- 1XDV
- Type
- protein
- Length
- 1,517 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Son of sevenless protein homolog 1
- UniProt
- Q07889
- Pockets
- 20 · best druggability 0.82
Structure
x-ray diffraction · 2 distinct chains · 58% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Son of sevenless protein homolog 1 | protein | 758 | 58% helix, 8% strand | Q07889 |
| B | Son of sevenless protein homolog 1 | protein | 759 | 58% helix, 8% strand | Q07889 |
Pockets
20 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1126 | 0.82 | 0.83 | 100 | empty |
| 2 | 503 | 0.71 | 0.81 | 53 | empty |
| 3 | 478 | 0.68 | 0.79 | 53 | empty |
| 4 | 595 | 0.67 | 0.77 | 50 | empty |
| 5 | 404 | 0.61 | 0.76 | 43 | empty |
Interfaces
1 interface between chains.
- A–B · 1735 Ų buried · 32 hydrogen bonds · protein-protein
Compared structures
- 1XDV · Experimentally Phased Structure of Human the Son of Sevenless protein at 4.1 Ang. · the same entry in another collection · chain A against A, TM-score 1.00
- Q07889 · AlphaFold monomer V2.0 prediction for son of sevenless homolog 1 (Q07889) · a predicted model of the same protein · chain B against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q07889
- Elsewhere: RCSB PDB 1XDV · PDBe 1XDV · UniProt Q07889
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