Research workbench
Experimentally phased structure of human the son of sevenless protein at 4.1 ang.
Analyse Experimentally phased structure of human the son of sevenless protein at 4.1… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1XDV
- Type
- protein
- Length
- 1,517 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Son of sevenless protein homolog 1
- UniProt
- Q07889
- Pockets
- 20 · best druggability 0.82
Structure
x-ray diffraction · 2 distinct chains · 58% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Son of sevenless protein homolog 1 | protein | 758 | 58% helix, 8% strand | Q07889 |
| B | Son of sevenless protein homolog 1 | protein | 759 | 58% helix, 8% strand | Q07889 |
Pockets
20 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1126 | 0.82 | 0.83 | 100 | empty |
| 2 | 503 | 0.71 | 0.81 | 53 | empty |
| 3 | 478 | 0.68 | 0.79 | 53 | empty |
| 4 | 595 | 0.67 | 0.77 | 50 | empty |
| 5 | 404 | 0.61 | 0.76 | 43 | empty |
Interfaces
1 interface between chains.
- A–B · 1735 Ų buried · 32 hydrogen bonds · protein-protein
Compared structures
- 1XDV · Experimentally Phased Structure of Human the Son of Sevenless protein at 4.1 Ang. · the same entry in another collection · chain A against A, TM-score 1.00
- Q07889 · AlphaFold monomer V2.0 prediction for son of sevenless homolog 1 (Q07889) · a predicted model of the same protein · chain B against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q07889
- Elsewhere: RCSB PDB 1XDV · PDBe 1XDV · UniProt Q07889
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