Research workbench
AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase SMURF2 (Q9HAU4)
Analyse AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase SMURF2… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- Q9HAU4
- Type
- protein
- Length
- 748 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x731d8ea2236F13759e0bE3C1C2bA23586AF10363
- Molecule
- E3 ubiquitin-protein ligase SMURF2
- UniProt
- Q9HAU4
- Pockets
- 9 · best druggability 0.78
Structure
1 distinct chain · 34% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | E3 ubiquitin-protein ligase SMURF2 | protein | 748 | 34% helix, 20% strand | Q9HAU4 |
Pockets
9 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1072 | 0.78 | 0.80 | 88 | empty |
| 2 | 622 | 0.67 | 0.77 | 56 | empty |
| 3 | 276 | 0.55 | 0.77 | 38 | empty |
| 4 | 231 | 0.54 | 0.78 | 24 | empty |
| 5 | 73 | 0.43 | 0.81 | 15 | empty |
Compared structures
- 7M3Q · Structure of the Smurf2 HECT Domain with a High Affinity Ubiquitin Variant (UbV) · an experimental structure of the same protein · chain A against A, TM-score 0.43
- 7M3Q · Structure of the SMURF2 hect domain with a high affinity ubiquitin variant (ubv) · an experimental structure of the same protein · chain A against A, TM-score 0.43
- 1ZVD · Regulation of SMURF2 ubiquitin ligase activity by anchoring the E2 to the hect domain · an experimental structure of the same protein · chain A against A, TM-score 0.41
- 1ZVD · Regulation of Smurf2 Ubiquitin Ligase Activity by Anchoring the E2 to the HECT domain · an experimental structure of the same protein · chain A against A, TM-score 0.41
- 2JQZ · Solution structure of the C2 domain of human SMURF2 · an experimental structure of the same protein · chain A against A, TM-score 0.17
- 2JQZ · Solution Structure of the C2 domain of human Smurf2 · an experimental structure of the same protein · chain A against A, TM-score 0.17
- 6FX4 · Disulfide between E3 hect ligase SMURF2 and ubiquitin G76C · an experimental structure of the same protein · chain A against C, TM-score 0.15
- 6FX4 · Disulfide between E3 HECT ligase Smurf2 and Ubiquitin G76C · an experimental structure of the same protein · chain A against C, TM-score 0.15
- 2KXQ · Solution structure of SMURF2 WW2 and WW3 bound to SMAD7 py motif containing peptide · an experimental structure of the same protein · chain A against A, TM-score 0.11
- 2KXQ · Solution Structure of Smurf2 WW2 and WW3 bound to Smad7 PY motif containing peptide · an experimental structure of the same protein · chain A against A, TM-score 0.11
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9HAU4
- Elsewhere: UniProt Q9HAU4 · AlphaFold DB Q9HAU4
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