UniProt Q9HAU4
E3 ubiquitin-protein ligase SMURF2 (Q9HAU4)
E3 ubiquitin-protein ligase SMURF2 (UniProt Q9HAU4), EC 2.3.2.26: 14 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 16 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q9HAU4
- Protein
- E3 ubiquitin-protein ligase SMURF2
- EC
- 2.3.2.26
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 16 · 3 records with a druggable one
Structures
15 records of Q9HAU4 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1ZVD | Regulation of Smurf2 Ubiquitin Ligase Activity by Anchoring the E2 to the HECT domain | x-ray diffraction | A | — | — |
| 1ZVD | Regulation of SMURF2 ubiquitin ligase activity by anchoring the E2 to the hect domain | x-ray diffraction | A | — | — |
| 2DJY | Solution structure of Smurf2 WW3 domain-Smad7 PY peptide complex | solution nmr | A | — | — |
| 2DJY | Solution structure of SMURF2 WW3 domain-SMAD7 py peptide complex | solution nmr | A | — | — |
| 2JQZ | Solution Structure of the C2 domain of human Smurf2 | solution nmr | A | — | — |
| 2JQZ | Solution structure of the C2 domain of human SMURF2 | solution nmr | A | — | — |
| 2KXQ | Solution Structure of Smurf2 WW2 and WW3 bound to Smad7 PY motif containing peptide | solution nmr | A | — | — |
| 2KXQ | Solution structure of SMURF2 WW2 and WW3 bound to SMAD7 py motif containing peptide | solution nmr | A | — | — |
| 2LTZ | Smurf2 WW3 domain in complex with a Smad7 derived peptide | solution nmr | A | — | — |
| 2LTZ | SMURF2 WW3 domain in complex with a SMAD7 derived peptide | solution nmr | A | — | — |
| 6FX4 | Disulfide between E3 HECT ligase Smurf2 and Ubiquitin G76C | x-ray diffraction | A, C | — | 4 (best 0.69) |
| 6FX4 | Disulfide between E3 hect ligase SMURF2 and ubiquitin G76C | x-ray diffraction | A, C | — | — |
| 7M3Q | Structure of the Smurf2 HECT Domain with a High Affinity Ubiquitin Variant (UbV) | x-ray diffraction | A | SO4, NA, CL | 3 (best 0.76) |
| 7M3Q | Structure of the SMURF2 hect domain with a high affinity ubiquitin variant (ubv) | x-ray diffraction | A | SO4, NA, CL | — |
| Q9HAU4 | AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase SMURF2 (Q9HAU4) | predicted | A | — | 9 (best 0.78) |
Ligands
Experiment against prediction
- 6FX4 chain A against the predicted model Q9HAU4: TM-score 0.96, RMSD 1.24 Å
- 6FX4 chain A against the predicted model Q9HAU4: TM-score 0.96, RMSD 1.24 Å
- 6FX4 chain C against the predicted model Q9HAU4: TM-score 0.96, RMSD 1.14 Å
- 6FX4 chain C against the predicted model Q9HAU4: TM-score 0.96, RMSD 1.14 Å
- 2JQZ chain A against the predicted model Q9HAU4: TM-score 0.91, RMSD 1.47 Å
- 2JQZ chain A against the predicted model Q9HAU4: TM-score 0.91, RMSD 1.47 Å
- 7M3Q chain A against the predicted model Q9HAU4: TM-score 0.79, RMSD 3.94 Å
- 7M3Q chain A against the predicted model Q9HAU4: TM-score 0.79, RMSD 3.94 Å
- 2DJY chain A against the predicted model Q9HAU4: TM-score 0.78, RMSD 1.84 Å
- 2DJY chain A against the predicted model Q9HAU4: TM-score 0.78, RMSD 1.84 Å
Elsewhere
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