MolNFT v1 · #30163 · protein
Regulation of SMURF2 ubiquitin ligase activity by anchoring the E2 to the hect domain
1ZVD · Smad ubiquitination regulatory factor 2: “Regulation of SMURF2 ubiquitin ligase activity by anchoring the E2 to the hect domain”. X-ray diffraction, 2 ligands (NA, PO4), 4 pockets (best druggability 0.60). MolNFT v1 #30163 on…
- PDB
- 1ZVD
- Type
- protein
- Length
- 373 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Smad ubiquitination regulatory factor 2
- EC
- 6.3.2.-
- UniProt
- Q9HAU4
- Ligands
- NA, PO4
- Pockets
- 4 · best druggability 0.60
Structure
x-ray diffraction · 1 distinct chain · 48% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) | protein | 373 | 48% helix, 15% strand | Q9HAU4 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 274 | 0.60 | 0.79 | 32 | empty |
| 2 | 67 | 0.59 | 0.90 | 24 | empty |
| 3 | 231 | 0.54 | 0.77 | 32 | empty |
| 4 | 127 | 0.44 | 0.77 | 23 | empty |
Modifications
Observed in the structure: 7 modified (engineered).
Compared structures
- 1ZVD · Regulation of Smurf2 Ubiquitin Ligase Activity by Anchoring the E2 to the HECT domain · the same entry in another collection · chain A against A, TM-score 1.00
- Q9HAU4 · AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase SMURF2 (Q9HAU4) · a predicted model of the same protein · chain A against A, TM-score 0.77
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9HAU4
- Elsewhere: RCSB PDB 1ZVD · PDBe 1ZVD · UniProt Q9HAU4
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