Research workbench
Regulation of SMURF2 ubiquitin ligase activity by anchoring the E2 to the hect domain
Analyse Regulation of SMURF2 ubiquitin ligase activity by anchoring the E2 to the hect… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1ZVD
- Type
- protein
- Length
- 373 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Smad ubiquitination regulatory factor 2
- EC
- 6.3.2.-
- UniProt
- Q9HAU4
- Ligands
- NA, PO4
- Pockets
- 4 · best druggability 0.60
Structure
x-ray diffraction · 1 distinct chain · 48% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) | protein | 373 | 48% helix, 15% strand | Q9HAU4 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 274 | 0.60 | 0.79 | 32 | empty |
| 2 | 67 | 0.59 | 0.90 | 24 | empty |
| 3 | 231 | 0.54 | 0.77 | 32 | empty |
| 4 | 127 | 0.44 | 0.77 | 23 | empty |
Modifications
Observed in the structure: 7 modified (engineered).
Compared structures
- 1ZVD · Regulation of Smurf2 Ubiquitin Ligase Activity by Anchoring the E2 to the HECT domain · the same entry in another collection · chain A against A, TM-score 1.00
- Q9HAU4 · AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase SMURF2 (Q9HAU4) · a predicted model of the same protein · chain A against A, TM-score 0.77
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9HAU4
- Elsewhere: RCSB PDB 1ZVD · PDBe 1ZVD · UniProt Q9HAU4
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.