Research workbench
AlphaFold monomer V2.0 prediction for sodium channel protein PAFPC1 (D0E0C2)
Analyse AlphaFold monomer V2.0 prediction for sodium channel protein PAFPC1 (D0E0C2) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- D0E0C2
- Type
- protein
- Length
- 1,553 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xFB04A69429e1aDF578Ed1736131a87ebE5d837bf
- Molecule
- Sodium channel protein PAFPC1
- UniProt
- D0E0C2
- Pockets
- 20 · best druggability 0.86
Structure
1 distinct chain · 65% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sodium channel protein PAFPC1 | protein | 1553 | 65% helix, 4% strand | D0E0C2 |
Pockets
20 pockets found on a 1 Å grid, 15 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1125 | 0.86 | 0.87 | 90 | empty |
| 2 | 1023 | 0.73 | 0.76 | 90 | empty |
| 3 | 488 | 0.71 | 0.80 | 46 | empty |
| 4 | 474 | 0.68 | 0.79 | 37 | empty |
| 5 | 451 | 0.66 | 0.78 | 34 | empty |
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- 6A91 · Complex of voltage-gated sodium channel NavPaS from American cockroach Periplaneta… · an experimental structure of the same protein · chain A against A, TM-score 0.79
- 6A91 · Complex of voltage-gated sodium channel navpas from american cockroach periplaneta… · an experimental structure of the same protein · chain A against A, TM-score 0.79
- 6A90 · Complex of voltage-gated sodium channel navpas from american cockroach periplaneta… · an experimental structure of the same protein · chain A against A, TM-score 0.79
- 6A90 · Complex of voltage-gated sodium channel NavPaS from American cockroach Periplaneta… · an experimental structure of the same protein · chain A against A, TM-score 0.79
- 5X0M · Structure of a eukaryotic voltage-gated sodium channel at near atomic resolution · an experimental structure of the same protein · chain A against A, TM-score 0.79
- 5X0M · Structure of a eukaryotic voltage-gated sodium channel at near atomic resolution · an experimental structure of the same protein · chain A against A, TM-score 0.79
- 6A95 · Complex of voltage-gated sodium channel NavPaS from American cockroach Periplaneta… · an experimental structure of the same protein · chain A against A, TM-score 0.78
- 6A95 · Complex of voltage-gated sodium channel navpas from american cockroach periplaneta… · an experimental structure of the same protein · chain A against A, TM-score 0.78
- 6NT3 · Cryo-EM structure of a human-cockroach hybrid nav channel. · an experimental structure of the same protein · chain A against A, TM-score 0.78
- 6NT3 · Cryo-EM structure of a human-cockroach hybrid Nav channel. · an experimental structure of the same protein · chain A against A, TM-score 0.78
- 6NT4 · Cryo-EM structure of a human-cockroach hybrid nav channel bound to alpha-scorpion toxin… · an experimental structure of the same protein · chain A against A, TM-score 0.78
- 6NT4 · Cryo-EM structure of a human-cockroach hybrid Nav channel bound to alpha-scorpion toxin… · an experimental structure of the same protein · chain A against A, TM-score 0.78
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt D0E0C2
- Elsewhere: UniProt D0E0C2 · AlphaFold DB D0E0C2
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