UniProt D0E0C2
Sodium channel protein PaFPC1 (D0E0C2)
Sodium channel protein PaFPC1 (UniProt D0E0C2): 17 experimental structures and 1 predicted model on GenesisL1, 15 ligands bound, 200 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- D0E0C2
- Protein
- Sodium channel protein PaFPC1
- Experimental structures
- 17
- Predicted models
- 1
- Ligands
- 15
- Pockets
- 200 · 10 records with a druggable one
Structures
18 records of D0E0C2 in the MolNFT archive: 17 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5X0M | Structure of a eukaryotic voltage-gated sodium channel at near atomic resolution | electron microscopy | A | NAG, BMA | — |
| 5X0M | Structure of a eukaryotic voltage-gated sodium channel at near atomic resolution | electron microscopy | A | NAG, BMA | — |
| 6A90 | Complex of voltage-gated sodium channel NavPaS from American cockroach Periplaneta americana and… | electron microscopy | A | NAG, NA | 20 (best 0.85) |
| 6A90 | Complex of voltage-gated sodium channel navpas from american cockroach periplaneta americana and… | electron microscopy | A | NAG, NA | — |
| 6A91 | Complex of voltage-gated sodium channel NavPaS from American cockroach Periplaneta americana bound… | electron microscopy | A | NAG, PC1, 9SL | 20 (best 0.87) |
| 6A91 | Complex of voltage-gated sodium channel navpas from american cockroach periplaneta americana bound… | electron microscopy | A | NAG, PC1, 9SL | — |
| 6A95 | Complex of voltage-gated sodium channel NavPaS from American cockroach Periplaneta americana bound… | electron microscopy | A | NAG, 9SR, NA | 20 (best 0.84) |
| 6A95 | Complex of voltage-gated sodium channel navpas from american cockroach periplaneta americana bound… | electron microscopy | A | NAG, 9SR, NA | — |
| 6NT3 | Cryo-EM structure of a human-cockroach hybrid Nav channel. | electron microscopy | A | NAG, BMA, Y01, 76F, LHG, AJP | — |
| 6NT3 | Cryo-EM structure of a human-cockroach hybrid nav channel. | electron microscopy | A | NAG, BMA, Y01, 76F, LHG, AJP | — |
| 6NT4 | Cryo-EM structure of a human-cockroach hybrid Nav channel bound to alpha-scorpion toxin AaH2. | electron microscopy | A | NAG, BMA, 76F, AJP, LHG, Y01 | 20 (best 0.86) |
| 6NT4 | Cryo-EM structure of a human-cockroach hybrid nav channel bound to alpha-scorpion toxin AAH2. | electron microscopy | A | NAG, BMA, 76F, AJP, LHG, Y01 | — |
| 8F0P | Structure of VSD4-NaV1.7-NaVPas channel chimera bound to the hybrid inhibitor GNE-1305 | electron microscopy | A | NAG, BMA, PEE, Y01, X7L | 20 (best 0.86) |
| 8F0Q | Structure of VSD4-NaV1.7-NaVPas channel chimera bound to the acylsulfonamide inhibitor GDC-0310 | electron microscopy | A | NAG, BMA, X7R, PEE, Y01 | 20 (best 0.85) |
| 8F0R | Structure of VSD4-NaV1.7-NaVPas channel chimera bound to the arylsulfonamide inhibitor GNE-3565 | electron microscopy | A | NAG, BMA, X7W, PEE, Y01 | 20 (best 0.87) |
| 8F0S | Structure of VSD4-NaV1.7-NaVPas channel chimera bound to the hybrid inhibitor GNE-9296 | electron microscopy | A | NAG, BMA, X80, PEE, Y01 | 20 (best 0.87) |
| 8VQC | Structure of the voltage-gated sodium channel NavPas from American Cockroach Periplaneta Americana… | electron microscopy | A | NAG, BMA | 20 (best 0.83) |
| D0E0C2 | AlphaFold monomer V2.0 prediction for sodium channel protein PAFPC1 (D0E0C2) | predicted | A | — | 20 (best 0.86) |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 17 records
- BMA · beta-D-mannopyranose · in 11 records
- Y01 · Cholesterol hemisuccinate · in 8 records
- 76F · (7E,21R,24S)-27-amino-24-hydroxy-18,24-dioxo-19,23,25-trioxa-24lambda~5~-phosphaheptacos-7-en-21-yl (9Z, 12E)-octadeca-9,12-dienoate · in 4 records
- AJP · Digitonin · in 4 records
- LHG · 1,2-dipalmitoyl-phosphatidyl-glycerole · in 4 records
- NA · Sodium ion · in 4 records
- PEE · 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine · in 4 records
- 9SL · [(3aS,4R,10aS)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3H,8H-pyrrolo[1,2-c]purin-4-yl]methyl carbamate · in 2 records
- 9SR · (1R,5R,6R,7R,9S,11S,12S,13S,14S)-3-amino-14-(hydroxymethyl)-8,10-dioxa-2,4-diazatetracyclo[7.3.1.1~7,11~.0~1,6~]tetradec-3-ene-5, 9,12,13,14-pentol (non-preferred name) · in 2 records
- PC1 · 1,2-diacyl-sn-glycero-3-phosphocholine · in 2 records
- X7L · N-[6-(cyclopentylmethoxy)-1,3-benzothiazol-2-yl]-4-{[(1S,2S)-2-(dimethylamino)cyclohexyl]amino}-2-fluorobenzene-1-sulfonamide · in 1 record
- X7R · 5-cyclopropyl-4-({1-[(1S)-1-(3,5-dichlorophenyl)ethyl]piperidin-4-yl}methoxy)-2-fluoro-N-(methanesulfonyl)benzamide · in 1 record
- X7W · 5-chloro-4-({(1S,2S,4S)-2-(dimethylamino)-4-[3-(trifluoromethyl)phenyl]cyclohexyl}amino)-2-fluoro-N-(pyrimidin-4-yl)benzene-1-sulfonamide · in 1 record
- X80 · 5-chloro-4-(cyclopentylmethoxy)-N-(4-{[(1S,2S)-2-(dimethylamino)cyclohexyl]amino}-2-fluorobenzene-1-sulfonyl)-2-fluorobenzamide · in 1 record
Experiment against prediction
- 8F0Q chain A against the predicted model D0E0C2: TM-score 0.97, RMSD 1.82 Å
- 8F0R chain A against the predicted model D0E0C2: TM-score 0.97, RMSD 1.84 Å
- 8F0S chain A against the predicted model D0E0C2: TM-score 0.97, RMSD 1.87 Å
- 8F0P chain A against the predicted model D0E0C2: TM-score 0.97, RMSD 1.89 Å
- 8F0Q chain A against the predicted model Q15858: TM-score 0.95, RMSD 2.59 Å
- 8F0R chain A against the predicted model Q15858: TM-score 0.95, RMSD 2.58 Å
- 6NT3 chain A against the predicted model D0E0C2: TM-score 0.95, RMSD 3.04 Å
- 6NT3 chain A against the predicted model D0E0C2: TM-score 0.95, RMSD 3.04 Å
- 8F0S chain A against the predicted model Q15858: TM-score 0.95, RMSD 2.52 Å
- 8F0P chain A against the predicted model Q15858: TM-score 0.95, RMSD 2.54 Å
Elsewhere
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