Research workbench
AlphaFold monomer V2.0 prediction for sodium channel protein type 5 subunit alpha (Q14524)
Analyse AlphaFold monomer V2.0 prediction for sodium channel protein type 5 subunit… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- Q14524
- Type
- protein
- Length
- 2,016 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x6a3E2329d7c8AC20c4D0EC099eda7556d5C5b2b5
- Molecule
- Sodium channel protein type 5 subunit alpha
- UniProt
- Q14524
- Pockets
- 20 · best druggability 0.86
Structure
1 distinct chain · 54% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sodium channel protein type 5 subunit alpha | protein | 2016 | 54% helix, 3% strand | Q14524 |
Pockets
20 pockets found on a 1 Å grid, 16 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1168 | 0.86 | 0.87 | 99 | empty |
| 2 | 877 | 0.76 | 0.79 | 85 | empty |
| 3 | 597 | 0.71 | 0.79 | 54 | empty |
| 4 | 519 | 0.70 | 0.79 | 44 | empty |
| 5 | 466 | 0.69 | 0.79 | 51 | empty |
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- 6LQA · voltage-gated sodium channel Nav1.5 with quinidine · an experimental structure of the same protein · chain A against B, TM-score 0.56
- 6LQA · Voltage-gated sodium channel NAV1.5 with quinidine · an experimental structure of the same protein · chain A against B, TM-score 0.56
- 7DTC · voltage-gated sodium channel Nav1.5-E1784K · an experimental structure of the same protein · chain A against A, TM-score 0.56
- 7DTC · Voltage-gated sodium channel NAV1.5-E1784K · an experimental structure of the same protein · chain A against A, TM-score 0.56
- 4OVN · Voltage-gated Sodium Channel 1.5 (Nav1.5) C-terminal domain in complex with Calmodulin… · an experimental structure of the same protein · chain A against H, TM-score 0.07
- 4OVN · Voltage-gated sodium channel 1.5 (NAV1.5) C-terminal domain in complex with calmodulin… · an experimental structure of the same protein · chain A against H, TM-score 0.07
- 4DCK · Crystal structure of the C-terminus of voltage-gated sodium channel in complex with FGF13… · an experimental structure of the same protein · chain A against A, TM-score 0.07
- 4DCK · Crystal structure of the C-terminus of voltage-gated sodium channel in complex with FGF13… · an experimental structure of the same protein · chain A against A, TM-score 0.07
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14524
- Elsewhere: UniProt Q14524 · AlphaFold DB Q14524
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