Research workbench
AlphaFold monomer V2.0 prediction for sodium channel protein type 4 subunit alpha (P35499)
Analyse AlphaFold monomer V2.0 prediction for sodium channel protein type 4 subunit… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- P35499
- Type
- protein
- Length
- 1,836 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xdF2b063d4B94F3f46D117B1af99A846bD4a59284
- Molecule
- Sodium channel protein type 4 subunit alpha
- UniProt
- P35499
- Pockets
- 20 · best druggability 0.85
Structure
1 distinct chain · 59% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sodium channel protein type 4 subunit alpha | protein | 1836 | 59% helix, 3% strand | P35499 |
Pockets
20 pockets found on a 1 Å grid, 18 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1156 | 0.85 | 0.85 | 90 | empty |
| 2 | 1168 | 0.75 | 0.77 | 99 | empty |
| 3 | 566 | 0.73 | 0.81 | 47 | empty |
| 4 | 969 | 0.71 | 0.75 | 68 | empty |
| 5 | 57 | 0.66 | 0.94 | 18 | empty |
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 6AGF · Structure of the human voltage-gated sodium channel NAV1.4 in complex with BETA1 · an experimental structure of the same protein · chain A against A, TM-score 0.61
- 6AGF · Structure of the human voltage-gated sodium channel Nav1.4 in complex with beta1 · an experimental structure of the same protein · chain A against A, TM-score 0.61
- 6MC9 · Crystal structure of human NAV1.4 C-terminal (1599-1754) domain in complex with… · an experimental structure of the same protein · chain A against A, TM-score 0.08
- 6MC9 · Crystal Structure of Human Nav1.4 C-Terminal (1599-1754) domain in complex with… · an experimental structure of the same protein · chain A against A, TM-score 0.08
- 6MBA · Crystal structure of human NAV1.4 cterminal domain in complex with apo calmodulin · an experimental structure of the same protein · chain A against A, TM-score 0.07
- 6MBA · Crystal Structure of Human Nav1.4 CTerminal Domain in Complex with apo Calmodulin · an experimental structure of the same protein · chain A against A, TM-score 0.07
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P35499
- Elsewhere: UniProt P35499 · AlphaFold DB P35499
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