UniProt P35499
Sodium channel protein type 4 subunit alpha (P35499)
Sodium channel protein type 4 subunit alpha (UniProt P35499): 4 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 22 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P35499
- Protein
- Sodium channel protein type 4 subunit alpha
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 22 · 2 records with a druggable one
Structures
5 records of P35499 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6AGF | Structure of the human voltage-gated sodium channel NAV1.4 in complex with BETA1 | electron microscopy | A | NAG, BMA, 6OU, 9Z9 | — |
| 6MBA | Crystal Structure of Human Nav1.4 CTerminal Domain in Complex with apo Calmodulin | x-ray diffraction | A | CL | 2 (best 0.70) |
| 6MBA | Crystal structure of human NAV1.4 cterminal domain in complex with apo calmodulin | x-ray diffraction | A | CL | — |
| 6MC9 | Crystal structure of human NAV1.4 C-terminal (1599-1754) domain in complex with calcium-bound… | x-ray diffraction | A | — | — |
| P35499 | AlphaFold monomer V2.0 prediction for sodium channel protein type 4 subunit alpha (P35499) | predicted | A | — | 20 (best 0.85) |
Ligands
- CL · Chloride ion · in 2 records
- 6OU · [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate · in 1 record
- 9Z9 · (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en · in 1 record
- BMA · beta-D-mannopyranose · in 1 record
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 1 record
Experiment against prediction
- 6AGF chain A against the predicted model P35499: TM-score 0.98, RMSD 1.56 Å
- 6MBA chain A against the predicted model P35499: TM-score 0.82, RMSD 2.53 Å
- 6MBA chain A against the predicted model P35499: TM-score 0.82, RMSD 2.53 Å
- 6MC9 chain A against the predicted model P35499: TM-score 0.78, RMSD 2.59 Å
Elsewhere
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