Crystal structure of human NAV1.4 cterminal domain in complex with apo calmodulin

Structure

x-ray diffraction · 2 distinct chains · 60% helix, 8% strand (DSSP).

Ligands and binding sites

• CL · Chloride ion · ion · 4 copies · chains A, B
• CO3 · Carbonate ion · ion · chains B
• EDO · 1,2-ethanediol · additive · chains B
• TRS · 2-amino-2-hydroxymethyl-propane-1,3-diol · additive · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 1582 Ų buried · 36 hydrogen bonds · protein-protein

Compared structures

• 6MBA · Crystal Structure of Human Nav1.4 CTerminal Domain in Complex with apo Calmodulin · the same entry in another collection · chain A against A, TM-score 1.00
• P35499 · AlphaFold monomer V2.0 prediction for sodium channel protein type 4 subunit alpha (P35499) · a predicted model of the same protein · chain A against A, TM-score 0.82
• P0DP29 · AlphaFold monomer V2.0 prediction for calmodulin-1 (P0DP29) · a predicted model of the same protein · chain B against A, TM-score 0.42

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P35499
• Every structure of UniProt P0DP29
• Elsewhere: RCSB PDB 6MBA · PDBe 6MBA · UniProt P35499 · UniProt P0DP29