Research workbench
AlphaFold monomer V2.0 prediction for exosome complex component RRP43 (P25359)
Analyse AlphaFold monomer V2.0 prediction for exosome complex component RRP43 (P25359) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- P25359
- Type
- protein
- Length
- 394 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x0D671490EE06E75975e90D7F99F73B20BE618744
- Molecule
- Exosome complex component RRP43
- UniProt
- P25359
- Pockets
- 5 · best druggability 0.45
Structure
1 distinct chain · 26% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Exosome complex component RRP43 | protein | 394 | 26% helix, 30% strand | P25359 |
Pockets
5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 160 | 0.45 | 0.75 | 21 | empty |
| 2 | 109 | 0.39 | 0.75 | 15 | empty |
| 3 | 57 | 0.37 | 0.80 | 15 | empty |
| 4 | 85 | 0.34 | 0.74 | 14 | empty |
| 5 | 73 | 0.33 | 0.75 | 17 | empty |
Compared structures
- 5C0X · Structure of a 12-subunit nuclear exosome complex bound to structured RNA · an experimental structure of the same protein · chain A against C, TM-score 0.84
- 4IFD · Crystal structure of an 11-subunit eukaryotic exosome complex bound to RNA · an experimental structure of the same protein · chain A against C, TM-score 0.84
- 4IFD · Crystal structure of an 11-subunit eukaryotic exosome complex bound to RNA · an experimental structure of the same protein · chain A against C, TM-score 0.84
- 6LQS · Cryo-EM structure of 90S small subunit preribosomes in transition states (State D) · an experimental structure of the same protein · chain A against R3, TM-score 0.84
- 6FSZ · Structure of the nuclear RNA exosome · an experimental structure of the same protein · chain A against CC, TM-score 0.84
- 7D4I · Cryo-EM structure of 90S small ribosomal precursors complex with the DEAH-box RNA… · an experimental structure of the same protein · chain A against R3, TM-score 0.84
- 5K36 · Structure of an eleven component nuclear RNA exosome complex bound to RNA · an experimental structure of the same protein · chain A against C, TM-score 0.82
- 5K36 · Structure of an eleven component nuclear RNA exosome complex bound to RNA · an experimental structure of the same protein · chain A against C, TM-score 0.82
- 5G06 · Cryo-EM structure of yeast cytoplasmic exosome · an experimental structure of the same protein · chain A against C, TM-score 0.80
- 5G06 · Cryo-EM structure of yeast cytoplasmic exosome · an experimental structure of the same protein · chain A against C, TM-score 0.80
- 5JEA · Structure of a cytoplasmic 11-subunit RNA exosome complex including Ski7, bound to RNA · an experimental structure of the same protein · chain A against C, TM-score 0.79
- 5JEA · Structure of a cytoplasmic 11-subunit RNA exosome complex including SKI7, bound to RNA · an experimental structure of the same protein · chain A against C, TM-score 0.79
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P25359
- Elsewhere: UniProt P25359 · AlphaFold DB P25359
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