UniProt P25359
Exosome complex component RRP43 (P25359)
Exosome complex component RRP43 (UniProt P25359): 15 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 5 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P25359
- Protein
- Exosome complex component RRP43
- Experimental structures
- 15
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 5 · 0 records with a druggable one
Structures
16 records of P25359 in the MolNFT archive: 15 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4IFD | Crystal structure of an 11-subunit eukaryotic exosome complex bound to RNA | x-ray diffraction | C | — | — |
| 4IFD | Crystal structure of an 11-subunit eukaryotic exosome complex bound to RNA | x-ray diffraction | C | — | — |
| 4OO1 | Structure of an Rrp6-RNA exosome complex bound to poly(A) RNA | x-ray diffraction | C | — | — |
| 4OO1 | Structure of an RRP6-RNA exosome complex bound to POLY(A) RNA | x-ray diffraction | C | — | — |
| 5C0W | Structure of a 12-subunit nuclear exosome complex bound to single- stranded RNA substrates | x-ray diffraction | C | — | — |
| 5C0X | Structure of a 12-subunit nuclear exosome complex bound to structured RNA | x-ray diffraction | C | — | — |
| 5G06 | Cryo-EM structure of yeast cytoplasmic exosome | electron microscopy | C | — | — |
| 5G06 | Cryo-EM structure of yeast cytoplasmic exosome | electron microscopy | C | — | — |
| 5JEA | Structure of a cytoplasmic 11-subunit RNA exosome complex including SKI7, bound to RNA | x-ray diffraction | C | — | — |
| 5K36 | Structure of an eleven component nuclear RNA exosome complex bound to RNA | x-ray diffraction | C | SO4 | — |
| 5K36 | Structure of an eleven component nuclear RNA exosome complex bound to RNA | x-ray diffraction | C | SO4 | — |
| 5OKZ | Crystal strucrure of the MPP6 exosome complex | x-ray diffraction | C, M, W, g | MG | — |
| 5VZJ | Structure of a twelve component MPP6-nuclear RNA exosome complex bound to RNA | x-ray diffraction | C | — | — |
| 6LQS | Cryo-EM structure of 90S small subunit preribosomes in transition states (State D) | electron microscopy | R3 | — | — |
| 7AJT | Cryo-EM structure of the 90S-exosome super-complex (state Pre-A1-exosome) | electron microscopy | ED | — | — |
| P25359 | AlphaFold monomer V2.0 prediction for exosome complex component RRP43 (P25359) | predicted | A | — | 5 (best 0.45) |
Ligands
Experiment against prediction
- 5JEA chain C against the predicted model P25359: TM-score 0.99, RMSD 0.82 Å
- 4IFD chain C against the predicted model P25359: TM-score 0.98, RMSD 1.20 Å
- 4IFD chain C against the predicted model P25359: TM-score 0.98, RMSD 1.20 Å
- 5C0X chain C against the predicted model P25359: TM-score 0.98, RMSD 1.20 Å
- 4OO1 chain C against the predicted model P25359: TM-score 0.98, RMSD 1.11 Å
- 4OO1 chain C against the predicted model P25359: TM-score 0.98, RMSD 1.11 Å
- 5VZJ chain C against the predicted model P25359: TM-score 0.98, RMSD 1.07 Å
- 7AJT chain ED against the predicted model P25359: TM-score 0.97, RMSD 1.20 Å
- 5OKZ chain M against the predicted model P25359: TM-score 0.97, RMSD 1.03 Å
- 5OKZ chain C against the predicted model P25359: TM-score 0.97, RMSD 1.03 Å
Elsewhere
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