Research workbench
AlphaFold monomer V2.0 prediction for piezo-type mechanosensitive ion channel component 1 (E2JF22)
Analyse AlphaFold monomer V2.0 prediction for piezo-type mechanosensitive ion channel… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- E2JF22
- Type
- protein
- Length
- 2,547 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x82785E70A1E767e03Fb666d37ebBB9690126A077
- Molecule
- Piezo-type mechanosensitive ion channel component 1
- UniProt
- E2JF22
- Pockets
- 20 · best druggability 0.80
Structure
1 distinct chain · 57% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Piezo-type mechanosensitive ion channel component 1 | protein | 2547 | 57% helix, 4% strand | E2JF22 |
Pockets
20 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 992 | 0.80 | 0.81 | 72 | empty |
| 2 | 850 | 0.78 | 0.81 | 68 | empty |
| 3 | 766 | 0.77 | 0.81 | 64 | empty |
| 4 | 465 | 0.76 | 0.84 | 48 | empty |
| 5 | 1079 | 0.75 | 0.77 | 74 | empty |
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 6B3R · Structure of the mechanosensitive channel Piezo1 · an experimental structure of the same protein · chain A against A, TM-score 0.48
- 6B3R · Structure of the mechanosensitive channel PIEZO1 · an experimental structure of the same protein · chain A against A, TM-score 0.48
- 7WLT · the Curved Structure of mPIEZO1 in Lipid Bilayer · an experimental structure of the same protein · chain A against A, TM-score 0.44
- 7WLT · The curved structure of MPIEZO1 in lipid bilayer · an experimental structure of the same protein · chain A against A, TM-score 0.44
- 7WLU · The Flattened Structure of mPIEZO1 in Lipid Bilayer · an experimental structure of the same protein · chain A against E, TM-score 0.43
- 7WLU · The flattened structure of MPIEZO1 in lipid bilayer · an experimental structure of the same protein · chain A against A, TM-score 0.43
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt E2JF22
- Elsewhere: UniProt E2JF22 · AlphaFold DB E2JF22
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.