UniProt E2JF22
Piezo-type mechanosensitive ion channel component 1 (E2JF22)
Piezo-type mechanosensitive ion channel component 1 (UniProt E2JF22): 17 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 140 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- E2JF22
- Protein
- Piezo-type mechanosensitive ion channel component 1
- Experimental structures
- 17
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 140 · 7 records with a druggable one
Structures
18 records of E2JF22 in the MolNFT archive: 17 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3JAC | Cryo-EM study of a channel | electron microscopy | A, B, C | — | — |
| 3JAC | Cryo-EM study of a channel | electron microscopy | A, B, C | — | — |
| 4RAX | A regulatory domain of an ion channel | x-ray diffraction | A | — | — |
| 4RAX | A regulatory domain of an ion channel | x-ray diffraction | A | — | — |
| 5Z10 | Structure of the mechanosensitive Piezo1 channel | electron microscopy | A, B, C | — | 20 (best 0.83) |
| 5Z10 | Structure of the mechanosensitive PIEZO1 channel | electron microscopy | A, B, C | — | — |
| 6B3R | Structure of the mechanosensitive channel Piezo1 | electron microscopy | A, C, E | — | 20 (best 0.82) |
| 6B3R | Structure of the mechanosensitive channel PIEZO1 | electron microscopy | A, C, E | — | — |
| 6BPZ | Structure of the mechanically activated ion channel Piezo1 | electron microscopy | A, B, C | — | 20 (best 0.81) |
| 6BPZ | Structure of the mechanically activated ion channel PIEZO1 | electron microscopy | A, B, C | — | — |
| 6LQI | Cryo-EM structure of the mouse Piezo1 isoform Piezo1.1 | electron microscopy | A, B, C | — | — |
| 6LQI | Cryo-EM structure of the mouse PIEZO1 isoform PIEZO1.1 | electron microscopy | A, B, C | — | — |
| 7WLT | the Curved Structure of mPIEZO1 in Lipid Bilayer | electron microscopy | A, C, E | PLX, PEE, P5S | 20 (best 0.85) |
| 7WLT | The curved structure of MPIEZO1 in lipid bilayer | electron microscopy | A, C, E | PLX, PEE | — |
| 7WLU | The flattened structure of MPIEZO1 in lipid bilayer | electron microscopy | A, C, E | PLX | — |
| 8IXN | Curved structure of mPIEZO1-S2472E | electron microscopy | C, A, D | PLX, PEE, P5S | 20 (best 0.84) |
| 8IXO | Intermediate structure of mPIEZO1-S2472E | electron microscopy | F, A, B | PLX, P5S, PEE | 20 (best 0.84) |
| E2JF22 | AlphaFold monomer V2.0 prediction for piezo-type mechanosensitive ion channel component 1 (E2JF22) | predicted | A | — | 20 (best 0.80) |
Ligands
- PLX · (9R,11S)-9-({[(1S)-1-hydroxyhexadecyl]oxy}methyl)-2,2-dimethyl-5,7,10-trioxa-2lambda~5~-aza-6lambda~5~-phosphaoctacosane-6,6,11-triol · in 5 records
- PEE · 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine · in 4 records
- P5S · O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy) propyl]oxy}(hydroxy)phosphoryl]-L-serine · in 3 records
Experiment against prediction
- 4RAX chain A against the predicted model E2JF22: TM-score 0.99, RMSD 0.77 Å
- 4RAX chain A against the predicted model E2JF22: TM-score 0.99, RMSD 0.77 Å
- 7WLT chain A against the predicted model E2JF22: TM-score 0.81, RMSD 3.77 Å
- 7WLT chain C against the predicted model E2JF22: TM-score 0.81, RMSD 3.77 Å
- 7WLT chain E against the predicted model E2JF22: TM-score 0.81, RMSD 3.77 Å
- 7WLT chain A against the predicted model E2JF22: TM-score 0.81, RMSD 3.77 Å
- 6B3R chain A against the predicted model E2JF22: TM-score 0.80, RMSD 4.19 Å
- 6B3R chain A against the predicted model E2JF22: TM-score 0.80, RMSD 4.19 Å
- 6B3R chain C against the predicted model E2JF22: TM-score 0.80, RMSD 4.19 Å
- 6B3R chain E against the predicted model E2JF22: TM-score 0.80, RMSD 4.19 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.