MolNFT v1 · #144319 · protein
Structure of the mechanically activated ion channel PIEZO1
6BPZ · Piezo-type mechanosensitive ion channel component 1,PIEZO…: “Structure of the mechanically activated ion channel PIEZO1”. Electron microscopy, 20 pockets (best druggability 0.81). MolNFT v1 #144319 on GenesisL1: 3D structure…
- PDB
- 6BPZ
- Type
- protein
- Length
- 2,700 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Piezo-type mechanosensitive ion channel component 1,PIEZO- type mechanosensitive ion…
- UniProt
- E2JF22
- Pockets
- 20 · best druggability 0.81
Structure
electron microscopy · 1 distinct chain · 60% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Piezo-type mechanosensitive ion channel component 1,PIEZO- type mechanosensitive ion channel component 1,MOUSE PIEZO1,PIEZO-type mechanosensitive ion channel component 1,PIEZO-type mechanosensitive ion channel component 1 | protein | 900 | 60% helix, 10% strand | E2JF22 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1007 | 0.81 | 0.82 | 107 | empty |
| 2 | 1077 | 0.81 | 0.82 | 113 | empty |
| 3 | 880 | 0.80 | 0.82 | 97 | empty |
| 4 | 863 | 0.80 | 0.83 | 87 | empty |
| 5 | 783 | 0.80 | 0.83 | 76 | empty |
Interfaces
3 interfaces between chains.
- B–C · 2773 Ų buried · 16 hydrogen bonds · protein-protein
- A–C · 2764 Ų buried · 16 hydrogen bonds · protein-protein
- A–B · 2755 Ų buried · 15 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 6BPZ · Structure of the mechanically activated ion channel Piezo1 · the same entry in another collection · chain A against A, TM-score 1.00
- E2JF22 · AlphaFold monomer V2.0 prediction for piezo-type mechanosensitive ion channel component 1… · a predicted model of the same protein · chain A against A, TM-score 0.71
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt E2JF22
- Elsewhere: RCSB PDB 6BPZ · PDBe 6BPZ · UniProt E2JF22
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