Research workbench
AlphaFold monomer V2.0 prediction for lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial (P11182)
Analyse AlphaFold monomer V2.0 prediction for lipoamide acyltransferase component of… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- P11182
- Type
- protein
- Length
- 482 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xc68aC5e94B8753FB46682724bd6fC29cf50d2c55
- Molecule
- Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase…
- UniProt
- P11182
- Pockets
- 3 · best druggability 0.58
Structure
1 distinct chain · 25% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial | protein | 482 | 25% helix, 21% strand | P11182 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 281 | 0.58 | 0.77 | 28 | empty |
| 2 | 198 | 0.49 | 0.75 | 27 | empty |
| 3 | 94 | 0.40 | 0.76 | 19 | empty |
Compared structures
- 1K8M · Solution Structure of the Lipoic Acid-Bearing Domain of the E2 component of Human… · an experimental structure of the same protein · chain A against A, TM-score 0.15
- 1K8M · Solution structure of the lipoic acid-bearing domain of the E2 component of human… · an experimental structure of the same protein · chain A against A, TM-score 0.15
- 1K8O · Solution structure of the lipoic acid-bearing domain of the E2 component of human… · an experimental structure of the same protein · chain A against A, TM-score 0.15
- 1K8O · Solution Structure of the Lipoic Acid-Bearing Domain of the E2 component of Human… · an experimental structure of the same protein · chain A against A, TM-score 0.15
- 2COO · Solution structure of the E3_BINDING domain of dihydrolipoamide branched chaintransacylase · an experimental structure of the same protein · chain A against A, TM-score 0.10
- 2COO · Solution structure of the e3_binding domain of dihydrolipoamide branched chaintransacylase · an experimental structure of the same protein · chain A against A, TM-score 0.10
- 3RNM · The crystal structure of the subunit binding of human dihydrolipoamide transacylase (E2b)… · an experimental structure of the same protein · chain A against E, TM-score 0.10
- 3RNM · The crystal structure of the subunit binding of human dihydrolipoamide transacylase (E2B)… · an experimental structure of the same protein · chain A against E, TM-score 0.10
- 1ZWV · Solution Structure of the subunit binding domain (hbSBD) of the human mitochondrial… · an experimental structure of the same protein · chain A against A, TM-score 0.09
- 1ZWV · Solution structure of the subunit binding domain (hbsbd) of the human mitochondrial… · an experimental structure of the same protein · chain A against A, TM-score 0.09
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P11182
- Elsewhere: UniProt P11182 · AlphaFold DB P11182
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