UniProt P11182
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial (P11182)
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial (UniProt P11182), EC 2.3.1.-, 2.3.1.168: 10 experimental structures and 1 predicted model on GenesisL1, 15 pockets.…
- UniProt
- P11182
- Protein
- Lipoamide acyltransferase component of branched-chain alpha-keto acid…
- EC
- 2.3.1.-, 2.3.1.168
- Experimental structures
- 10
- Predicted models
- 1
- Pockets
- 15 · 7 records with a druggable one
Structures
11 records of P11182 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1K8M | Solution Structure of the Lipoic Acid-Bearing Domain of the E2 component of Human, Mitochondrial… | solution nmr | A | — | 1 (best 0.53) |
| 1K8M | Solution structure of the lipoic acid-bearing domain of the E2 component of human, mitochondrial… | solution nmr | A | — | 1 (best 0.53) |
| 1K8O | Solution Structure of the Lipoic Acid-Bearing Domain of the E2 component of Human, Mitochondrial… | solution nmr | A | — | 1 (best 0.56) |
| 1K8O | Solution structure of the lipoic acid-bearing domain of the E2 component of human, mitochondrial… | solution nmr | A | — | 1 (best 0.56) |
| 1ZWV | Solution Structure of the subunit binding domain (hbSBD) of the human mitochondrial branched-chain… | solution nmr | A | — | — |
| 1ZWV | Solution structure of the subunit binding domain (hbsbd) of the human mitochondrial branched-chain… | solution nmr | A | — | — |
| 2COO | Solution structure of the e3_binding domain of dihydrolipoamide branched chaintransacylase | solution nmr | A | — | — |
| 2COO | Solution structure of the E3_BINDING domain of dihydrolipoamide branched chaintransacylase | solution nmr | A | — | — |
| 3RNM | The crystal structure of the subunit binding of human dihydrolipoamide transacylase (E2b) bound to… | x-ray diffraction | E, F | — | 4 (best 0.71) |
| 3RNM | The crystal structure of the subunit binding of human dihydrolipoamide transacylase (E2B) bound to… | x-ray diffraction | E, F | — | 4 (best 0.71) |
| P11182 | AlphaFold monomer V2.0 prediction for lipoamide acyltransferase component of branched-chain… | predicted | A | — | 3 (best 0.58) |
Experiment against prediction
- 3RNM chain F against the predicted model P11182: TM-score 0.94, RMSD 0.50 Å
- 3RNM chain F against the predicted model P11182: TM-score 0.94, RMSD 0.50 Å
- 3RNM chain E against the predicted model P11182: TM-score 0.88, RMSD 1.15 Å
- 3RNM chain E against the predicted model P11182: TM-score 0.88, RMSD 1.15 Å
- 1ZWV chain A against the predicted model P11182: TM-score 0.64, RMSD 2.96 Å
- 1ZWV chain A against the predicted model P11182: TM-score 0.64, RMSD 2.96 Å
- 1K8M chain A against the predicted model P11182: TM-score 0.64, RMSD 3.42 Å
- 1K8M chain A against the predicted model P11182: TM-score 0.64, RMSD 3.42 Å
- 1K8O chain A against the predicted model P11182: TM-score 0.63, RMSD 2.98 Å
- 1K8O chain A against the predicted model P11182: TM-score 0.63, RMSD 2.98 Å
Elsewhere
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